IL-8与溃疡性结肠炎复发的关系及中药抗复发的研究  

Relationship of IL-8 with Recurrence of Ulcerative Colitis and Anti-recurrence Mechanism of Herbal Medicine

作　　者：郭雁冰[1] 王新月[2] 林燕[3] 

机构地区：[1]解放军306医院,北京100101 [2]东直门医院,北京100700 [3]北京中医药大学,北京100000

出　　处：《新中医》2008年第2期52-53,共2页New Chinese Medicine

摘　　要：目的:探讨白细胞介素8(IL-8)与溃疡性结肠炎(UC)复发的相互关系及中药抗溃疡性结肠炎复发的机制。方法:将108例患者,随机分为2组各54例,治疗组(脱落3例)采用理气健脾、活血生肌中药治疗,对照组(脱落2例)采用柳氮磺胺吡啶治疗,观察治疗后6月复发率,检测患者血清、结肠IL-8含量变化,并设健康志愿者为正常组作血清、结肠IL-8对照。结果:治疗前UC患者血清、结肠IL-8水平均明显高于正常组(P<0.001),复发UC患者血清IL-8含量和结肠IL-8表达明显高于未复发患者(P<0.001)。治疗后治疗组血清、结肠IL-8水明显低于对照组(P<0.01,P<0.001)。随访时治疗组血清、结肠IL-8水平均明显低于对照组(P<0.001);与同组治疗后比较,随访时治疗组差异无显著性意义,而对照组差异有显著性意义(P<0.001)。结论:IL-8过度表达与UC复发有关,中药抗UC复发可能是通过对IL-8的抑制作用而实现的。Objective:To investigate the relationship of IL-8 with recurrence of ulcerative colitis (UC)and to explore the anti-recurrence mechanism of berbal medicine.Methods:One hundred and eight UC patients were equally randomized into two groups.Group A(3 patients being dropoff) received herbal medicine with the actions of regulating Qi and strengthening spleen,activating blood and promoting granulation.Group B(2 patients being dropoff)received sulfasalazine.The recur- rence rate was observed after treatment for 6 months,and the IL-8 level in the serum and colon was compared with that in the healthy volunteers.Results:Before treatment,IL-8 level in the serum and colon of UC was higher than that in the healthy volunteers(P<0.001 ),and IL-8 lev- el in recurrent UC patients higher than that in UC patients(P<0.001).After treatment and during the follow-up,IL-8 level in group A was lower than that in group B(P<0.01 or P<0.001). The difference of IL-8 in group A after treatment was insignificant as compared with that during follow-up while was significant in group B(P<0.001 ).Conclusion:The over-expression of IL-8 contributes to the recurrence of UC,and the anti-recurrence mechanism of herbal medicine is related with the inhibition of IL-8 level.

关 键 词：溃疡性结肠炎 IL-8 复发 补气药 活血祛瘀药 

分 类 号：R259.746.2[医药卫生—中西医结合]