Synthesis and Crystal Structure of Chiral 4-Hydroxy-4-butyrolactam Fused Aziridine  

作　　者：WANG Jian-Ping WANG Jian-Ge FU Yong-Ju LI Ying-Fei 

机构地区：[1]Department of Chemistry, Luoyang Normal University, Luoyang 471022, China [2]Chemical Engineering ＆ Pharmaceutics College, Henan University of Science and Technology, Luoyang 471003, China

出　　处：《Chinese Journal of Structural Chemistry》2008年第2期133-136,共4页结构化学（英文）

基　　金：Project supported by key subject of Luoyang Normal University (No. 2004yzk90)

摘　　要：A novel compound of chiral 4-hydroxy-4-butyrolactam fused aziridine was synthesized via tandem nucleophilic displacement reaction under mild condition. Its structure was determined by IR, 1H NMR, elemental analysis and X-ray diffraction. The crystal of the new compound is of orthorhombic, space group P212121 with a = 6.4246（6）, b = 13.5081（13）, c = 18.6399（18） A, Mr = 278.39, Z = 4, V = 1617.6（3）A^3, Dc = 1.143 g/cm^3, p（MoKa） = 0.075 mm^-1, F（000） = 608, the final R = 0.0297 and wR = 0.0679.A novel compound of chiral 4-hydroxy-4-butyrolactam fused aziridine was synthesized via tandem nucleophilic displacement reaction under mild condition. Its structure was determined by IR, 1H NMR, elemental analysis and X-ray diffraction. The crystal of the new compound is of orthorhombic, space group P212121 with a = 6.4246（6）, b = 13.5081（13）, c = 18.6399（18） A, Mr = 278.39, Z = 4, V = 1617.6（3）A^3, Dc = 1.143 g/cm^3, p（MoKa） = 0.075 mm^-1, F（000） = 608, the final R = 0.0297 and wR = 0.0679.

关 键 词：butyrolactam AZIRIDINE asymmetric synthesis crystal structure 

分 类 号：O623.73[理学—有机化学]