生物可降解明胶微球的制备及体外降解  

Preparation and In-vitro Degradation of Biodegradable Gelatin Microspheres

作　　者：姜丹[1] 唐召军[2] 姜云垒[3] 刘成柏[1] 王飞[1] 林相友[1] 陈霞[1] 

机构地区：[1]吉林大学生命科学学院,长春130021 [2]河南大学特种功能材料重点实验室,河南开封475001 [3]吉林农业大学动物科技学院,长春130018

出　　处：《吉林大学学报（理学版）》2008年第1期143-147,共5页Journal of Jilin University:Science Edition

基　　金：国家转基因重大科研项目基金(批准号:JY03-B-16-02)

摘　　要：以生物可降解明胶为载体,采用乳化交联法制备明胶微球,考察了固化剂加入时间对微球质量的影响,并通过正交实验研究了明胶溶液的浓度、搅拌速度、水油相比例对微球粒径的影响.结果表明,所制备的明胶微球,具有粒径均一、成球率高的特点,微球表面平滑,平均粒径为13.72μm.Gelatin microspheres were prepared by means of emulsion chemical-crossline technique. In order to gain the best homogeneous size and parameters, it was demonstrated that solidifying reagent adding time had effects on gelatin microspheres. The preparation conditions of the microspheres such as gelatin concentration, agitate rate, ratio of water to oil phase were studied and discussed. The surface morphology and the size of the microspheres were observed by SEM. The result shows that the microspheres prepared have relatively uniform diameter, the average diameter in this study is 13.72 μm, and the surface of the microspheres is smooth.

关 键 词：明胶 微球 乳化交联法 固化剂 正交设计 

分 类 号：R944.9[医药卫生—药剂学]