HBV宫内感染与孕期使用乙肝免疫球蛋白关系  

Association of administration of hepatitis B immunoglobulin during pregnancy with intrauterine infection of HBV

作　　者：邵中军[1] 李晶华[2] 徐德忠[3] 姜庆五[3] 徐剑秋 

机构地区：[1]复旦大学公共卫生学院流行病学教研室,上海200333 [2]第四军医大学西京医院中医科 [3]第四军医大学预防医学系流行病学教研室 [4]陕西省妇幼保健院产科

出　　处：《中国公共卫生》2008年第2期135-136,共2页Chinese Journal of Public Health

基　　金：国家自然科学基金重点项目(30230320)

摘　　要：目的探讨孕期使用乙肝免疫球蛋白对乙型肝炎病毒(HBV)宫内感染的保护作用及其对孕妇病毒滴度的影响。方法以HBsAg阳性孕妇及其新生儿为研究对象,以孕期使用过乙肝免疫球蛋白的孕妇为干预组,其余为对照组,比较2组乙型肝炎病毒(HBV)宫内传播发生率、病毒载量的差异,探讨乙肝免疫球蛋白的保护作用及其机制。结果干预组孕妇210例,有10例新生儿发生宫内感染;对照组402例,有15例发生宫内感染,差异无统计学意义。相关分析显示,乙肝免疫球蛋白使用剂量与HBV DNA拷贝数、HBsAg滴度无关。结论孕期使用乙肝免疫球蛋白不能降低孕妇病毒载量,对HBV宫内传播也无保护作用。Objective To explore the protective effect of HBIG administrated during pregnancy against HBV intrauterine infection and its candidate mechanism. Methods 210 HBsAg positive pregnant women who were consecutively collected and were administered with HBIG were selected as intervention group. 402 consecutively collected HBsAg positive pregnant women who were not administered with HBIG were selected as controls. Incidence of HBV intrauterine transmission was compared between 2 groups. Titer of HBsAg and copies of HBV DNA in maternal sera of intervention group were detected for explorating its considerate mechanism. Results Ten neonates in intervention group and 15 in control group were detected as occurrence of HBV intrauterine infection and the difference was non significant by Chi - square test. There were no significant relation between titer of HBsAg or copies of HBV DNA and frequency of HBIG administration with R - value 0. 039 or 0. 012 respectively （P 〉 0.05）. Conclusion HBIG administration during pregnancy didn＇t decrease the titer of Ht3sAg and copies of HBV DNA, and the protective effect on HBV intrauterine infection was not found.

关 键 词：乙肝免疫球蛋白 宫内传播 乙型肝炎 

分 类 号：R512.62[医药卫生—内科学]