血清铁蛋白与原发性高血压关系病例对照研究  

Case-control study on relationship between serum ferritin and essential hypertension

作　　者：赵景波[1] 王建炳[2] 李健杰[2] 王付曼[2] 扬利婷[2] 李素洁[3] 聂绍发[1] 

机构地区：[1]华中科技大学同济医学院公共卫生学院流行病与卫生统计学系,武汉430030 [2]哈尔滨医科大学公共卫生学院流行病学教研室 [3]黑龙江省电力医院体检中心

出　　处：《中国公共卫生》2008年第2期198-200,共3页Chinese Journal of Public Health

基　　金：黑龙江省自然科学基金(D200623)

摘　　要：目的探讨血清铁蛋白与原发性高血压是否存在关联,为高血压病因研究提供基础依据。方法采用病例对照研究方法,以黑龙江省电力医院健康检查中心诊断的高血压患者及非高血压者各78人为调查对象,测量血压、身高、体重、腰围、臀围及对吸烟、饮酒的调查。现场采集空腹静脉血并分离血清,检测血脂、空腹血糖、血清铁蛋白等指标。统计分析采用SAS 9.1统计软件,分析上述指标在高血压组和非高血压组人群中的差异。结果年龄、性别、吸烟率和饮酒率在高血压组与非高血压组的差异均无统计学意义(P>0.05)。高血压组的甘油三酯(TG)、低密度脂蛋白胆固醇(LDL)水平均显著高于非高血压组(P<0.01)。高血压组空腹血糖、体质指数(BMI)和腰臀比(WHR)均高于非高血压组(P<0.01)。单因素分析结果显示,血清铁蛋白与原发性高血压、收缩期高血压、舒张期高血压均有关(P<0.05),OR值分别为3.41,2.40,2.57。使用多因素Logistic回归分析调整年龄、性别等混杂因素影响后,血清铁蛋白与原发性高血压、舒张期高血压差异仍有统计学意义,OR值分别为2.78,2.60。血清铁蛋白与收缩期高血压无关联。结论血清铁蛋白与原发性高血压、舒张期高血压相关联,但与收缩期高血压无关联。Objective To explore the association between essential hypertension and serum ferritin and lay a foundation for etiokigical study of hypertension. Methods The population of Heilongjiang Newspaper Office were selected as subjects to conduct case - control study （ case： 76 ; control; 76）. All subjects were interviewed with questionnaire and measured for blood pressure, stature, weight, waist circumference, hip circumference and investigated for risk factors of life style （ smoking and drinking）. Blood specimens were collected for detecting serum lipid, fasting plasma glucose, serum ferritin. All data were analyzed with SAS 9.1 software. Results There was no significant difference for age and gender between the hypertensives and normotensives （P〉 0.05）. The exposed proportion of alcohol drinking and smoking had no significant difference in two groups. The average levels of TG, LDL - c in hypertensives were higher than those in the normotensives. Both the body mass index （BMI） and ratio of waist to hip circumference （WHR） were significantly higher in the hypertensives than those in the normotensives （ P 〈 0.01 ）. The level of fasting plasma glucose （FPG） were higher in the hypertensives than those in the normotensives. Data from univariate analysis showed serum ferritin was related to essential hypertension, systolic hypertension and diastolic hypertension, OR s were 3.41, 2.40, 2.57 respectively. After adjusting for confounding factors by logistic regression, serum ferritin was still associated with essential hypertension and diastolic hypertension, OR s were 2.54, 2.49 respectively, but not with systolic hypertension. Conclusion The study confirmed that serum ferritin was related to essential hypertension and diastolic hypertension, but not systolic hypertension.

关 键 词：原发性高血压 收缩期高血压 舒张期高血压 血清铁蛋白 

分 类 号：R544.1[医药卫生—心血管疾病]