纳米靶向技术在智能释药系统的应用  

Applications of Targeting Nanotechnology in Intelligent Drug Release System

作　　者：黄建艳[1] 汤顺清[1] 蔡继业[2] 

机构地区：[1]暨南大学生物医学工程研究所,广州510632 [2]暨南大学化学系,广州510632

出　　处：《材料导报》2007年第F11期27-29,36,共4页Materials Reports

摘　　要：智能纳米靶向释药载体能对外界环境的温度、pH值、电、磁、化学物质等的刺激信号做出响应,并控制药物按设定目标释放。根据不同机理,纳米靶向技术分生物靶向、理化靶向及复合靶向3种。综述了纳米靶向技术在智能释药系统的最新应用研究进展。随着纳米技术的进一步发展和现有技术的不断完善,纳米载体智能释药系统在实际应用中会大规模采用,为人类战胜疾病作出贡献。Intelligent nanocarriers can control drug release to the target sites, which are responsive to the external stimuli, such as temperature, pH, electricity, magnetism and some chemicals. According to the differences of the targeting mechanisms, targeting nanotechnologies may be classified into biotargeting system, physical and chemical targeting system and complex targeting system. This paper reviews the recent applications of targeting nanotechnology in intelligent drug release system. It＇s believed that with the development of nanotechnology, intelligent drug release system will be extensively used and make great progress in the human′s healthy.

关 键 词：纳米载体 控制释放系统 靶向 

分 类 号：TB383[一般工业技术—材料科学与工程] TQ460.6[化学工程—制药化工]