窦房结缺血再灌注的细胞凋亡研究进展  

Progresses about Apoptosis of Sinoatrial Node Cells Induced by Ischemia-Reperfusion

作　　者：谭双[1] 刘如秀[1] 

机构地区：[1]中国中医科学院广安门医院心内科,北京100053

出　　处：《医学综述》2008年第1期1-3,共3页Medical Recapitulate

基　　金：国家中医药管理局资助项目(04-05JP61)

摘　　要：病态窦房结综合征是临床常见病,其发病机制目前尚不完全清楚。鉴于该病常伴随缺血性心脏病而出现,故窦房结缺血再灌注诱导细胞凋亡可能为其原因之一。在窦房结的发育、成熟过程中,凋亡不足可留下引发心律失常的基础,凋亡过度可引起病态窦房结综合征等病变。采用抑制窦房结病理性细胞凋亡的措施,可望为临床防治病态窦房结综合征提供新的方法。中药具有效果明显,副作用小的优点,如何利用中药来诱导机体产生内源性心脏保护作用是现代中医面临的一个崭新课题。Sick sinus syndrome（SSS） is a common clinical problem, of which the pathogenesis is not very clear. Because it is often accompanyed by ischemic heart diseases, apaptosis resulting from ischemia-reparfusion of sinus node maybe the one of the reasons. During the procedure of growth and mature, deficient apaptosis will result in pathogenic basis of arrhythmia, while excessive apaptosis will result in sick sinus syndrome and so on. Methods inhibiting pathologic apaptosis of si-nus node will provide new methods for the therapy and prevention of SSS in clinic. Traditional Chinese medicine has obvious efficacy with less adverse effect,how to use this drug to induce endoge-netic cardiac oreservation is the new topic in modem traditional Chinese medicine.

关 键 词：窦房结 细胞凋亡 缺血再灌注 

分 类 号：R541.74[医药卫生—心血管疾病] R322.11[医药卫生—内科学]