去铁敏对缺血再灌注组织的保护作用  

Protective Effect of Deferoxamine on Tissue with Ischemia-reperfusion

作　　者：冯敏[1] 张培建[1] 刘新颜[1] 

机构地区：[1]扬州大学第二临床医学院普通外科,江苏扬州225009

出　　处：《医学综述》2008年第1期96-97,共2页Medical Recapitulate

基　　金：江苏省科技厅社会发展科技项目(BS2004536);江苏省扬州市科技局社会发展科技项目(YZ20004048)

摘　　要：去铁敏作为一种经典的高效的铁离子螯合剂能降低缺血再灌注组织中铁的含量,抑制铁驱动的氧化毒性反应,从而起到对缺血再灌组织的保护作用;另外,组织中铁离子浓度的降低,使在常氧下低氧诱导因子1的降解受到阻碍、转录得以增加,最终去铁敏可以通过增加组织细胞内低氧诱导因子1的含量来发挥对缺血再灌注组织的保护作用。As a traditional ferri ion chelator with high efficacy,Deferoxamine can protect the tissue with ischemia-reperfusion by decreasing the ferric contents in tissue with ischemia-reperfusion and in-hibiting oxidized toxic reaction promoted by ferric. Besides that, decreased ferric concentration in tissue can block thedegradation of hypoxia-inducible factor-1 （HIF-1） in normal oxygen concentration and in-crease the transcription, so deferoxamine can exert its protective effect on tissue with ischemia-reperfusion by increasing the contents of HIF in tissues and cells.

关 键 词：去铁敏 低氧诱导因子1 缺血再灌注 

分 类 号：R453.9[医药卫生—治疗学]