血脂8项指标在缺血性脑血管疾病中的应用评价  

Application and evaluation of eight blood-lipids indices in ischemic cerebrovascular diseases

作　　者：尹杰[1] 肇玉博[1] 

机构地区：[1]陕西中医学院附属医院检验科,陕西咸阳712000

出　　处：《检验医学与临床》2008年第3期149-150,共2页Laboratory Medicine and Clinic

摘　　要：目的了解胆固醇、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)及低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A1、载脂蛋白B、非高密度脂蛋白胆固醇(non-HDL-C)、血浆促动脉硬化指数(AIP)在缺血性脑血管疾病中的应用价值。方法使用全自动生化分析仪对116例缺血性脑血管疾病患者和30例健康者进行血脂检测,并按照有关公式计算non-HDL-C、LDL-C、AIP,对结果进行统计学分析。结果在短暂性脑缺血发作时,AIP与健康对照组比较,差异有统计学意义,AIP的曲线下面积(AUC)为0.682。在脑动脉硬化时,non-HDL-C、AIP、HDL-C与对照组比较,差异有统计学意义,non-HDL-C、AIP、HDL-C的AUC分别为0.860、0.807和0.716。脑梗死时,non-HDL-C、AIP、HDL-C、LDL-C与对照组比较,差异有统计学意义,non-HDL-C、AIP、HDL-C、LDL-C的AUC分别为0.765、0.812、0.764和0.695。结论在短暂性脑缺血发作时,AIP、TG应用价值较高;脑动脉硬化时,AIP、non-HDL-C、LDL-C具有较高应用价值;脑梗死时,AIP、non-HDL-C、HDL-C具有较高应用价值。Objective To understand the applicable value of total cholesterol （TC）, triglyceride （TG）, high density lipoprotein-cholesterol（ HDL-C）, low density lipoprotein-cholesterol（ LDL-C）, apolipoprotein A1 （ ApoA1 ）, apolipoprotein B （ApoB）, non-high density lipoprotein-cholesterol（non-HDL-C）, atherogenic index of plasma （AIP） in ischemic cerebrovascular diseases （ICD）. Methods 116 patients with ischemic cerebrovascular diseases and 30 healthy subjects were involved in the investigation. Fully automatic biochemical analyzer was utilized to examine the levels of blood lipids. Non-HDL-C, LDL-C and AIP were calculated according to related formula, and the results were statistically analyzed. Results Compared with that of control group, the level of AIP in transient ischemic attack group was significant higher, and its area under curve （AUC） was 0. 682. There were significant differences of non-HDL-C, AIP and HDL-C between cerebral atherosclerosis group and control group. The AUC of non-HDL-C, AIP and HDL-C in cerebral atherosclerosis group was 0. 860,0. 807 and 0. 716 respectively. There were significant differences of non-HDL-C, AIP, HDL-C and LDL-C between cerebral infarction group and control group. The AUC of non-HDL-C, AIP, HDL-C and LDL-C in cerebral infarction group was 0. 765,0. 812, 0. 764 and 0. 695 respectively. Conclusion AIP and TG is of higher applicable value for ischemic cerebrovascular diseases, AIP, non-HDL-C and LDL-C for cerebral arteriosclerosis, while AIP, non-HDL-C and HDL-C for cerebral infarction.

关 键 词：脑血管疾病 胆固醇 三酰甘油 曲线下面积 

分 类 号：R446.1[医药卫生—诊断学]