我国戊型肝炎病毒87A株实验感染恒河猴的研究  

A study on experimental infection of rhesus monkeys with strain 87A of hepatitis E virus

作　　者：黄如统[1] 魏君[1] 李德荣[1] 田辛[1] 殷书荣[1] 洪松芳[1] 

机构地区：[1]军事医学科学院微生物学流行病学研究所

出　　处：《军事医学科学院院刊》1997年第3期190-193,共4页Bulletin of the Academy of Military Medical Sciences

摘　　要：用组织培养分离的戊型肝炎病毒（ＨＥＶ）８７Ａ株病毒液，以后腿静脉内接种４只恒河猴，其中２只在感染后第５周血清转氨酶（ＡＬＴ）开始升高，最高值达到感染前猴的将近２倍，升高后肝活检可见特征性病理学改变，并从混合粪便悬液中又分离出相同的病毒；感染的动物ＨＥＶ特异性抗体全部转阳。而２只对照猴无上述感染症状。Four rhesus monkeys were infected by inoculation to the leg vein with strain 87A of HEV. Of them, two infected monkeys developed elevated ALT level, their liver biopsy showed histopathological changes and virus was isolated by cell culture of the mixed feces of two infected animals. Specific antibody to HEV was revealed in all infected animals. The result shows that the strain 87A is a hepatotropic virus.

关 键 词：戊型肝炎病毒 87A株 感染 恒河猴 

分 类 号：R373.21[医药卫生—病原生物学] R-332[医药卫生—基础医学]