刺乌头碱对麻醉大鼠心电图的影响及其抗实验性心律失常作用  

Effect of lappaconitine on ECG in anesthetized rats and its anti arrhythmic action

作　　者：王培德[1,2] 马学民[1,2] 张慧灵[1,2] 杨玉梅[1,2] 杨煜荣[1,2] 王洪诚[1,2] 劳爱娜[1,2] 

机构地区：[1]包头医学院药理教研室 [2]中国科学院上海药物研究所

出　　处：《中国药理学通报》1997年第3期263-265,共3页Chinese Pharmacological Bulletin

摘　　要：目的与方法：给麻醉大鼠恒速ｉｖ刺乌头碱观察ＥＣＧ变化及ｉｐ小剂量刺乌头碱对动物实验性心律失常的影响。结果：ｉｖ剂量至２．５４±０．０６ｍｇ·ｋｇ－１时，ＨＲ显著减慢，Ｐ－Ｒ间期显著延长，当剂量增至４．１２～８．１９ｍｇ·ｋｇ－１时，可分别引起ＶＰ、ＶＴ、ＶＦ及ＣＡ等；经ｉｐ０．５ｍｇ·ｋｇ－１时，则能对抗乌头碱、氯化钡诱发的大鼠心律失常，显著提高哇巴因诱发豚鼠心律失常的剂量。结论：小剂量刺乌头碱具有抗心律失常作用，而大剂量又可诱发心律失常。AIM & METHODS:The effects of lappaconitine (LA) on ECG infused in a constant rate in anesthetized rats and the effects of a low dose of LA(ip) on experimental arrhythmia were studied. RESULTS:LA decreased significantly the heart rates and increased markedly the P R intervals at iv dose of 2 54±0 06 mg·kg -1 . Up to 4 12￣8 19 mg·kg -1 , LA caused ventricular premature beats (VP), ventricular tachycardia (VT), ventricular fibrillation (VF) and cardiac arrest (CA), respectively. LA (0 5 mg·kg -1 , ip) prevented the arrhythmias induced by aconitine and BaCl 2 in rats and increased significantly the doses of ouabain to induce arrhythmias in guinea pigs. CONCLUSIONS:A low dose of LA can prevent the arrhythmias, whereas the high dose of LA can induce the arrhythmia and their relationship seems to be the therapeutic action and the toxic reaction in heart of some anti arrhythmic drugs.

关 键 词：刺乌头碱 心电图 心律失常 高乌头 生物碱 

分 类 号：R972.2[医药卫生—药品] R282.710.5[医药卫生—药学]