呋喃丙吡啶对再灌注心肌顿抑兔血小板聚集和血压的影响  

1,4 Dihydropyridines in the brief postischemic reperfused myocardium:its effects on platelet aggregation and blood pressure

作　　者：贾勤惠[1,2,3,4] 贾国良[1,2,3,4] 梅其炳 裴其应[1,2,3,4] 王妍 

机构地区：[1]兰州军区乌鲁木齐总医院老年科 [2]第四军医大学西京医院心内科 [3]第四军医大学药理教研室 [4]第四军医大学西京医院临床检验科

出　　处：《中国药理学通报》1997年第3期265-267,共3页Chinese Pharmacological Bulletin

摘　　要：目的：探讨心肌顿抑发生后血流动力学和血小板聚集率的变化，以及钙通道拮抗剂呋喃丙吡啶对心肌顿抑兔的保护作用。方法：经冠状动脉结扎法建立兔心肌顿抑模型。用药组缺血前用呋喃丙吡啶静脉给药。结果：对照组再灌注后１５ｍｉｎ血浆最大血小板聚集率达高峰（６１．７６％±９．２２％），用药组同一时间点血浆最大血小板聚集率较对照组低（４０．２３％±５．３９％，Ｐ＜０．０１）。对照组血压较缺血前明显下降（Ｐ＜０．０５），用药组：Ⅰ组（１ｍｇ·ｋｇ－１）血压变化与对照组无统计学差异，Ⅱ组（３ｍｇ·ｋｇ－１）缺血后舒张压下降明显与对照组相比差异显著，随着再灌注时间延长舒张压逐步回升。结论：心肌顿抑发生后伴有血流动力学变化及血小板聚集率增高，缺血前静脉应用呋喃丙吡啶治疗对心肌损伤具有保护作用。AIM:To study the changes of the hemodynamic reperfused myocardium (stunned myocardium) and cardio protective effects of calcium antagonist F 3 (1,4 dihydropyridines). METHODS:Rabbits were surgically prepared for coronary arterial occlusion and reperfusion. F 3 was used in the treatment during ischemia. RESULTS:Administration of calcium antagonist F 3(1, 4 dihydropyridines, 3 mg·kg -1 iv) reduced the degree of platelet aggregation dramatically [(40 23%±5 39%) P <0 01],as compared with those in controls platelet aggregation (61 76%±9 22%) . Blood pressure was significantly different from that of the preischemic. CONCLUSIONS:The results suggest that changes of the hemodynamic and platelet aggregation in stunned myocardium. This study demonstrated that F 3 improves hemodynamic changes and significantly inhibited platelet aggregation in stunned myocardium.

关 键 词：心肌顿抑 血小板 呋喃丙吡啶 血压 

分 类 号：R972[医药卫生—药品] R965.1[医药卫生—药学]