不稳定型心绞痛患者血小板反应素-1基因G1678A多态性分析  

Relationship between G1678A polymorphism of thrombospondin-1 gene and unstable angina pectoris

作　　者：何国平[1] 高磊[1] 杨国英[1] 马继政[2] 杨笛[2] 张寄南[2] 

机构地区：[1]江苏大学附属武进医院心内科,江苏常州213002 [2]南京医科大学第一附属医院心血管病研究所

出　　处：《临床心血管病杂志》2007年第11期845-847,共3页Journal of Clinical Cardiology

基　　金：江苏省高新技术研究(No:BG2003033)

摘　　要：目的:探讨血小板反应素-1(TSP-1)基因G1678A(Ala523Thr)多态性与中国汉族人群不稳定型心绞痛(UAP)的关系。方法:应用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法,检测110例UAP患者(UAP组)和319例非冠心病者(对照组)的TSP-1G1678A多态性。结果:TSP-1G1678A多态性AA、GA和GG基因型频率在UAP组和对照组的分布差异无统计学意义(AA,46.4%∶40.4%;GA,40.0%∶46.1%;GG,13.6%∶13.5%,均P>0.05)。A等位基因频率在UAP组(66.4%)和对照组(63.5%)分布差异也无统计学意义(P>0.05)。结论:TSP-1基因G1678A多态性与中国汉族人群UAP无显著相关性。Objective： To investigate the possible association between the thrombospondin-1 （TSP-1） gene G1678A （Ala523Thr） polymorphism and unstable angina pectoris（UAP） in a Chinese Han population. Method： This study was conducted with a case-control design including 110 patients with UAP and 319 age-and sex-matched control subjects who were free from coronary artery disease. The TSP-1 G1678A polymorphism was determined by polymerase chain reaction and restriction fragment length polymorphism analysis. Result：The frequencies of genotypes of the G1678A polymorphism were not significantly different between patients with UAP and controls（AA ： 46.4 % vs 40.4 %,, ;P= 0.27 ; GA： 40.0% vs 46.1%, P=0.26; GG： 13.6% vs 13.5%, P=0.96）. The frequencies of A allele in ＇the UAP group and control group were 66.4% and 63.5%, respectively（P=0.44）. Conclusion：The present findings suggest that the TSP-1 gene G1678A polymorphism may be not associated with an increased risk for UAP in the Han population of China. The findings further supplement experimental data for TSP-1 gene study of the coronary disease.

关 键 词：心绞痛 不稳定型 血小板反应素 基因多态性 

分 类 号：R541.4[医药卫生—心血管疾病]