葡萄糖氯化钠钾注射液与注射用阿昔洛韦、更昔洛韦配伍的稳定性  

Compatible stabilities of glucose and sodium chloride potassium chloride injection mixing with aciclovir and ganciclovir for injection

作　　者：王艳红[1] 陈晓辉[1] 魏京海[2] 毕开顺[1] 

机构地区：[1]沈阳药科大学药物分析教研室,沈阳110016 [2]首都医科大学附属北京儿童医院药剂科,北京100045

出　　处：《中国临床药学杂志》2007年第6期379-381,共3页Chinese Journal of Clinical Pharmacy

摘　　要：目的研究在室温下葡萄糖氯化钠钾注射液分别与注射用阿昔洛韦、更昔洛韦配伍后的稳定性。方法采用HPLC法分别测定配伍后阿昔洛韦和更昔洛韦的含量变化,同时考察配伍溶液的外观、pH值和不溶性微粒的变化。结果在室温下配伍溶液8h内均无气体或沉淀产生,pH值、不溶性微粒和含量均无明显变化。结论葡萄糖氯化钠钾注射液与注射用阿昔洛韦、更昔洛韦配伍后8h稳定,在8h内可安全应用于临床。AIM To observe the stabilities of glucose and sodium chloride potassium chloride injection mixing with aciclovir and ganciclovir at 25℃.METHODS RP-HPLC was applied to determine the content changing of aciclovir and ganciclovir in different time.The pH,quantity of non-soluble particulate and appearance of mixtures were also observed.RESULTS In room temperature the mixtures produced neither gas nor sediment.The pH,quantity of non-soluble particulate and content did not change markedly within 8 h.CONCLUSION The mixtures of glucose and sodium chloride potassium chloride injection mixing with aciclovir and ganciclovir are stable in 8 h,and can be safely used in the clinic.

关 键 词：配伍稳定性 葡萄糖氯化钠钾注射液 阿昔洛韦 更昔洛韦 

分 类 号：R942[医药卫生—药剂学]