四生汤促进骨髓粒系造血祖细胞增殖的实验研究  

Experiment with Si Sheng Decoction in promoting the proliferation of hemopoietic stem cells in marrow

作　　者：凌昌全[1,2] 史剑慧[1,2] 陈哲 张红武[1,2] 

机构地区：[1]第二军医大学附属长海医院中医科 [2]上海市放射医学研究所

出　　处：《中国中医基础医学杂志》1997年第4期21-23,共3页JOURNAL OF BASIC CHINESE MEDICINE

摘　　要：四生汤促进骨髓粒系造血祖细胞增殖的实验研究＊凌昌全１史剑慧２陈哲１张红武１（１第二军医大学附属长海医院中医科上海２００４３３）（２上海市放射医学研究所上海２０００３２）在应用四生汤（又名“减毒一号”）减轻放疗所致患者造血功能损伤（尤其是外周血白细胞减...It has been proved that Si Sheng Decoction (SSD) may alleviate the γ ray adverse effects and have a good clinical curative effect. To probe into the mechanisms of it, we made the mice model irradiated by 137 Cs γ ray once all over the body and the effects of SSD on the number of peripheral leucocytes, marrow karyocytes and CFU S in mice were observed. The results showed that the number of marrow karyocytes could be increased by SSD and SSD could protect the hemopoietic stem cells from the damage caused by γ ray. The study in vitro also suggested that SSD enhance the production of G CFU in human marrow. According to the results, we infer that some factors exist in SSD, which promots the proliferation and differentiation of the hemopoietic stem cells in marrow. It is one of the mechanisms of alleviating the γ ray adverse effects by SSD and worth further studying what the curative factors in SSD are. Protections of Eliminating Phlegm and Removing Blood Stasis on the Vascular Emdothedium of Experimental Hyperlipedemic Rats Zhou Xia jing,(周暇菁),Song Jian nan(宋,et al. Institute of Basic Theory, China Academy of TCM Beijing 100700,China Abstract\ This peper reports that the effects of preparation of eliminating phlegm and removing blood stasis on Vascular endothelium permeability on secretion. The results showed that the preparation could decreased vascular endothelium permeability, reduced plasma and RBC membrane MDA contents, kept No and6 keto PGF 1α on the mormal levels, adjusted the balance of b keto PGF 1α /TXB 2α . The r between MDA and NO or permeability were very significant.

关 键 词：四生汤 中药 方剂 骨髓 粒系造血祖细胞 增殖 

分 类 号：R289.5[医药卫生—方剂学]