骨微损伤、骨重建与代谢性骨病  

Role of microdamage in bone remodeling and metabolic bone diseases

作　　者：马育林[1] 戴如春[1] 廖二元[1] 

机构地区：[1]中南大学湘雅二医院代谢内分泌研究所,长沙410011

出　　处：《国际病理科学与临床杂志》2007年第6期525-529,共5页Journal of International Pathology and Clinical Medicine

基　　金：国家自然科学基金资助项目(30400514);湖南省自然科学基金(06JJ50029);卫生部临床学科重点建设资助项目(2004-468-50)~~

摘　　要：骨微损伤能启动骨重建,骨重建障碍而导致微损伤积累可引发骨折。扫描电镜、同步加速器射线μ-CT和高分辨磁共振显像是研究骨微损伤的新方法,骨理化构成和年龄对微损伤发生和发展有重要影响,骨细胞在微损伤修复中起重要作用,骨微损伤研究有利于代谢性骨病防治。Microdamage can trigger bone remodeling. Failing of remodeling will result in accumulation of microdamage and subsequent fracture. Scanning electron microscopy, synchrotron radiation μ-CT and high resolution magnetic resonance imaging are the advanced methods of microdamage detecting. The age, physical and chemical makeup of bone influence the initiation and propagation of microdamage. Osteocytes play a crucial role in the repairing of micrdamage. The study of bone microdamage would contribute to the prevention and treatment of metabolic bone diseases.

关 键 词：骨微损伤 骨微损伤检测 骨重建 骨细胞 骨微结构 代谢性骨病 

分 类 号：R580[医药卫生—内分泌] R68[医药卫生—内科学]