秋水仙碱辅助治疗黄疸型肝炎的临床研究  

Clinical observation on the treatment with colchicin for icteric hepatitis

作　　者：潘雪飞[1] 张长法[1] 陈小凤[1] 

机构地区：[1]解放军第454医院,江苏南京210002

出　　处：《东南国防医药》2007年第6期415-416,424,共3页Military Medical Journal of Southeast China

摘　　要：目的研究秋水仙碱辅助治疗黄疸型肝炎的临床价值。方法进行临床对照观察,治疗组患者在常规治疗方案基础上口服秋水仙碱0.5m g,每天2次,连续6~8周。结果秋水仙碱治疗1周血清总胆红素即下降37.88%,对照组则为25.95%,两组比较有显著性差异（P〈0.05）;秋水仙碱治疗第6周血清总胆红素复常例数高于对照组,有非常显著性差异（P〈0.01）;治疗组血清胆红素平均复常时间为（36.3±12.8）天,亦明显优于对照组（47.9±21.6）天,差异非常显著（P〈0.01）。结论秋水仙碱适合有淤胆倾向之中、重度黄疸型肝炎患者,能快速降低血清胆红素,从而缩短疗程。Objective To study the clinical effect of colchicin on icteric hepatitis. Methods The patients were divided into two groups： the control group was given routine therapy while the treatment group was given routine therapy with oral colchicin, 0. 5mg twice per day for 6-8 weeks. Results The effect of the treatment group was slightly prior to the control group without significant difference. Nevertheless 37.88%of the serum total bilirubin（TBil） of the treatment group descended while 25.95% of the control group with a significant difference （P〈0.05） in the end of the first week. After 6 weeks, the patients whose serum TBil returned normal in the treatment group were higher than that in the control group with a significant difference（P〈0. 01）. The mean time in which the serum TBil became normal on （36. 3=k 12. 8）d, was better than that of the control group which on （47.9±21.6 ）d with significant difference （P〈 0.01 ） . Conclusion Colchicin adapts to the severe icteric hepatitis with a tendency of cholestasis because the serum level of TBil can be descended rapidly,thereby and the time of therapy and inhospital is shorten.

关 键 词：秋水仙碱 黄疸 胆红素 肝炎 

分 类 号：R512.6[医药卫生—内科学]