前列舒通对丙酸睾酮诱导的去势大鼠前列腺增生的作用机制  

The mechanism of action of using Qianlie Shutong to treat the hyperplasia of prostate induced by Testosterone in castrated rat

作　　者：李祥光[1] 张亚强[1] 宋竖旗[1] 鞠大宏[2] 

机构地区：[1]中国中医科学院广安门医院泌尿外科,北京100053 [2]中国中医科学院基础理论研究所病理室

出　　处：《中国男科学杂志》2007年第12期25-28,35,共5页Chinese Journal of Andrology

摘　　要：目的探讨前列舒通抑制良性前列腺增生的治疗作用机理,观察其对良性前列腺增生的治疗效果。方法观察前列舒通作用于丙酸睾酮诱导去势大鼠前列腺增生模型后的前列腺指数,前列腺体积,前列腺腺体总面积、bFGF(碱性成纤维生长因子)、EGF(表皮生长因子)、bcl-2(抑制细胞凋亡因子),以及前列腺组织病理学改变。结果前列舒通各浓度组前列腺指数、前列腺体积、前列腺腺体总面积、bFGF、EGF、bcl-2均明显低于模型组。结论前列舒通能显著抑制丙酸睾酮诱导去势大鼠的良性前列腺增生,其机制可能是通过降低bFGF、EGF、bcl-2的表达水平,从而抑制前列腺细胞增殖和促进凋亡而实现的。Objective To study the mechanism of action of using Qianlie Shutong to inhibit benign prostatic hyperplasia, and observe the effect of treatment at the same time. Methods Hyperplasia of prostate induced by Testosterone in castrated rat were treated by Qianlie Shutong, and the corresponding index, include the prostate index, prostate volume, prostate gland area, bFGF, EFG, bcl-2, and the pathological changes of prostate gland were measured. Results The level of the prostate index, prostate volume, prostate gland area, bFGF, EFG, bcl-2 of each Qianlie Shutong dose group were obviously lower than that of the model group. Conclusion Qianlie Shutong Can significantly inhibit the hyperplasia of prostate induced by Testosterone in castrated rat, the possible mechanism is to lower the level of bFGF, EGF, bc1-2, and accordingly, Inhibit the prostate cell proliferation and promote the apoptosis.

关 键 词：前列舒通 前列腺增生 细胞增殖 细胞凋亡 

分 类 号：R697.33[医药卫生—泌尿科学]