维库溴铵靶控输注与间断静注临床效果比较  

Comparison of clinical effect of target-controlled infusion and intermittent bolus injection of vecuronium

作　　者：唐岩峰[1] 张禾田[2] 李军[1] 

机构地区：[1]温州医学院附属第二医院,浙江温州325027 [2]吉林大学附属第三医院,吉林长春132021

出　　处：《现代中西医结合杂志》2008年第4期497-498,502,共3页Modern Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的观察靶控输注技术(TCI)维持肌松可否改变随机静注肌松药的缺点和不足,从而为临床选出一种给药方法。方法将30例拟行胃肠手术的患者随机分为间断静注维库溴铵组(A组)和TCI组(B组),观察2组患者术毕至气管导管拔管时间、手术开始及手术刺激最强时T1/Tc值及术毕前30 min内出现体动需要追加镇静或镇痛药例数。结果B组拔管时间明显缩短(P<0.05),手术开始及手术刺激最强时T1/Tc值明显低于A组(P<0.01)。结论静脉TCI泵注维库溴铵是一种科学合理的麻醉给药方法。Objective It is to observe whether target-controlled infusion （TCI） used for muscle relaxation maintaining can overcome the disadvantages of intermittent bolus injection of muscle relaxation drugs, so to screen a better medication for clinic. Methods 30 patients scheduled to undergo abdominal surgery were randomly divided into TCI group （group B） and intermittent bolus injection of vecuronium group （group A）. Time from operation end to puling out endotracheal tube, T1/Tc value at operation beginning and at the time when the operation stimulus was most intensive, cases needed more sedatives or analgesic 30 min before operation end were observed. Results Time from operation end to puling out endotracheal tube in group B was obviously shortened （P （0.05）, T1/Tc value at operation beginning and at the time when the operation stimulus was most intensive was significantly lower than that in group A （P 〈0.01）. Conclusion Vein TCI of vecuronium is a scientific and possible anesthesia medication.

关 键 词：维库溴铵 靶控输注 神经肌肉阻滞 

分 类 号：R614[医药卫生—麻醉学]