含O-(1,2,2,2-四氯)乙基-O-取代苯基硫逐磷酰胺酯的合成、结构表征和生物活性  

Synthesis, Characterization and Biological Activity of O (1,2,2,2 tetrachloro)ethyl O Substituted Phenyl Phosphoramidothionates

作　　者：李盛彪[1,2] 黄世强[1,2] 何良年 黄天宝[1,2] 周青春 张景龄[1,2] 

机构地区：[1]湖北大学化学系 [2]华中师范大学有机合成研究所

出　　处：《应用化学》1997年第2期45-49,共5页Chinese Journal of Applied Chemistry

基　　金：国家自然科学基金

摘　　要：以取代的苯氧基替代烷氧基，合成了２１种新的Ｏ－（１，２，２，２－四氯）乙基－Ｏ－取代苯基硫逐磷酰胺酯．通过元素分析、ＩＲ、１ＨＮＭＲ、３１ＰＮＭＲ和ＭＳ对化合物进行鉴定．Ｏ－（１，２，２，２－四氯）乙基硫逐磷酰肼在碱性条件下可容易地生成１，３，４，２－口恶二唑磷杂环戊烷．并确定了其质谱裂解机制．生物活性普筛结果表明，个别化合物具有高效防治根结线虫活性．Twenty one new O (1,2,2,2 tetrachloro)ethyl O substituted phenyl phosphoramidothionates were synthesized and their structures were characterized through IR, NMR( 1H、 31 P) and MS. The O (1,2,2,2 tetrachloro)ethyl thiophosphoric hydrazides could be transferred into 1,3,4,2 oxadiazaphospholanes under alkaline condition. The biological activity of the products was also tested and some compounds showed a high activity against nematode.

关 键 词：硫逐磷酰胺酯 合成 生物活性 恶二唑磷杂环 

分 类 号：O627.51[理学—有机化学]