绝经早期激素与中药治疗对认知记忆和生存质量的影响  

Effect of Hormone and Chinese Traditional Medicine Treatment on Cognition and Memory and Quality of Life in the Women at the Early Stage of Menopause

作　　者：龚莉莉 张绍芬 纪律 

机构地区：[1]复日大学附属妇产科医院,上海200011

出　　处：《生殖与避孕》2008年第1期26-31,共6页Reproduction and Contraception

基　　金：国家十五攻关项目,项目编号:2004BA720A08

摘　　要：目的:研究绝经早期激素和中药治疗对认知记忆和生存质量的影响。方法:收集绝经早期妇女104例,随机分为激素组和中药组各52例,治疗1年,每3个月随访1次,由专人进行简易智能精神状态量表(MMSE)和绝经期生存质量量表评分。结果:激素组和中药组在治疗后6个月、9个月、12个月MMSE评分较治疗前均有显著性提高(P<0.05)。绝经期生存质量量表中的血管舒缩症状、心理状态、生理状态方面,二组在治疗后各时间点上均比治疗前有明显提高(P<0.05)。性生活方面,激素组用药6个月开始出现明显改善,而中药组用药12个月始有明显提高。结论:绝经早期低剂量激素替代疗法和中药治疗1年对改善认知记忆和提高生存质量均有效。Objective：To study effect of hormone and Chinese Traditional Medicine treatment on cognition and memory and quality of life in the women at the early stage of menopause. Methods： A total of 104 perimenopausal women who had perimenopausal syndrome were enrolled in this trial. They were randomly assigned to hormone group（HG） and Chinese Traditional Medicine group（CG） and treated for 1 year. They came to visit every 3 months. Mini-mental state examination（MMSE） and perimenopausal daily life score were assessed by a special doctor. Results： Both HG and CG had improvement in MMSE after 6 months, 9 months and 12 months. The two groups had significantly benefit in vasomotor, physical and psychosocial domain after treatment. In the sexual domain, the HG got better after 6 months whereas the CG appeared effective after 12 months. Conclusion： HRT was effective in improving cognition and memory and quality of dailylife. So was the Chinese Traditional Medicine treatment.

关 键 词：绝经早期 激素替代治疗(HRT) 中药坤泰胶囊 认知记忆 生存质量 

分 类 号：R711.75[医药卫生—妇产科学]