妊娠期急性脂肪肝8例临床分析  

Clinical analysis of 8 cases of acute fatty liver during Pregnancy.

作　　者：姜玉霞[1] 王竹梅[2] 

机构地区：[1]潍坊市妇幼保健医院妇产科,山东261011 [2]潍坊市人民医院妇产科,261000

出　　处：《中国优生与遗传杂志》2008年第1期85-86,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨妊娠期急性脂肪肝(AFLP)的临床特点,以利及时诊断和治疗。方法就对近1O年我院收治的8例AFLP患者的临床资料进行回顾性分析。结果8例患者中6例为初产妇,2例经产妇。以无诱因出现恶心、呕吐、进行性黄疸等消化道症状及肝功能损害为主要表现,短期内出现多脏器功能衰竭、DIC。化验检查:血清白蛋白降低、凝血酶原时间延长、纤维蛋白原降低、血清转氨酶升高、血清总胆红素、直接胆红素升高、低血糖、白细胞升高、血小板下降。8例患者均剖宫产终止妊娠,其中2例因子宫出血行全子宫切除术。孕产妇死亡2例,围产儿死亡1例。结论早期诊断、及时终止妊娠和支持治疗是提高AFLP母儿预后的关键。Objective：To explore the clinical features of acute fattyliver of pregnancy（AFLP）.for early diagnose and management in timely.Methods：The clinical findings and outcome of pregnancy were analyzed in 8 patients with AFLP at our hospital in recent 10 years.Results：6 in 8 patients is primigravidaes and 2 are multiparas.Digest symptom that the patient complains nausea.vomiting and carrying on sex jaundice having in predisposing factors and liver function damage is main performance,in the short time having some multi-organ failure and DIC.The result of test：albumin decreasing.clotting time prolonging.fibrinogen decreasing,transaminase elevating,bilirubin elevating,blood-fasting sugar decreasing and platelets decreasing.8 patients all terminated gestation by caesarean section and 2 of them were hysterectomied because uterus bled.2 pregnant women and l neonate died.Conclusion：The key point to increase the mortality of mother and children who are prone to suffer with AFLP is to understand its characters,to make early diagnosis,and to terminate pregnancy timely.

关 键 词：妊娠期急性脂肪肝 诊断 治疗 

分 类 号：R714.2[医药卫生—妇产科学]