非典型抗精神病药物在双相障碍治疗中的应用  

The application of atypical anti-psychotics in bipolar disorder therapy

作　　者：沙莎[1] 张鸿燕[1] 

机构地区：[1]北京大学精神卫生研究所,北京100083

出　　处：《中国新药杂志》2008年第1期5-11,共7页Chinese Journal of New Drugs

摘　　要：非典型抗精神病药物由于其自身独特的药理学特性,除了用于治疗精神分裂症外,其对双相障碍的疗效日益受到关注。目前较为明确的是,无论是单一用药还是与心境稳定剂联用,多数非典型抗精神病药用于控制双相障碍的急性躁狂发作均安全有效;其中奥氮平和喹硫平对双相障碍抑郁发作的疗效也得到了肯定。除此之外,有关非典型抗精神病药用于混合发作的治疗、稳定期的维持治疗、预防复发以及一些特殊类型如快速循环型双相障碍的治疗等的探索研究也在不断深入进行中。Due to their own special pharmacological characteristics, besides the therapeutical effect of schizophrenia,the application of atypical anti-psychotics in bipolar disorder therpy has become more and more absorbing. What we can relatively identify is that regardless of monotherapy or combinated with mood stabilizer,most atypical anti-psychotics were safe and effective when used in treating acute manic patients of bipolar disorder in most cases. Among them,olanzapine and quetiapine have also been proved to be effective to the psycholepsy. Besides, exploratory development toward the therapy of mixed state, maintenance, relapse prevention and some special types,such as rapid-cycled bipolar disorder,etc,have also become the focus of attention increasingly.

关 键 词：非典型抗精神病药物 双相障碍 临床应用 

分 类 号：R971.43[医药卫生—药品]