化痰降气胶囊制备工艺研究  

Study on the Extracting Procedure and Preparation of Huatan Jiangqi Capsules

作　　者：高家荣[1] 章俊如[1] 李霁明[1] 

机构地区：[1]安徽中医学院第一附属医院药学部,合肥230031

出　　处：《中国药师》2008年第1期41-43,共3页China Pharmacist

基　　金：国家中医药管理局新药开发专项课题(D1X031A)

摘　　要：目的:优选化痰降气胶囊最佳制备工艺。方法:采用正交试验法,以浸膏得率及盐酸麻黄碱含量为指标,优选药材乙醇提取工艺;以挥发油含量为提取工艺筛选指标;以挥发油利用率和包合物收率为包合工艺评价指标。结果:药材提取最佳工艺为:以70%乙醇为提取溶媒,加液量8倍,提取2次,时间分别为2h,1h;挥发油最佳提取条件搭配为:10倍水,浸泡1 h,提取4h,当归挥发油包合最佳工艺为:每1ml挥发油用10gβ-环湖精(β-CD),100ml水,60℃搅拌包合2h。结论:正交试验法为制备化痰降气胶囊提供依据。Objective： To select the optimal preparing procedures of Huatan Jiangqi capsules. Method ： The preparing procedures were optimized on the basis of ephedrine hydrochloride content and the yield of extraction. The volume of the volatile oil was used to evaluate the extraction process and percentage recovery of inclusion compound, transfer rate of oil was used to evaluate the inclusion process by the orthogonal design. Result： The materials were extracted with 8-fold amount of 70% ethanol and the extraction time was 2 h,lh,for 2 times. The best volatile oil extraction condition was to add 10 folds water into the crude drugs, to soak for 1 hour and to reflux for 4 hours. And the optimum inclusion condition was β-CD： volatile oil in proportion as 10：1 was mixed in 100 ml water, refluxing and stirring for 2 h at 60℃. Conclusion： The process selected in this experiment is practicable and applied for preparation of Huatan Jiangqi capsules.

关 键 词：化痰降气胶囊 盐酸麻黄碱 正交试验 β-环湖精 

分 类 号：R283.65[医药卫生—中药学]