金银花中裂环环烯醚萜苷类化学成分研究  

Secoiridoid glycosides from Flos Lonicerae

作　　者：毕跃峰[1] 田野[1] 裴姗姗[1] 刘宏民[1] 

机构地区：[1]郑州大学新药研究开发中心,河南郑州450001

出　　处：《中草药》2008年第1期18-21,共4页Chinese Traditional and Herbal Drugs

摘　　要：目的系统研究金银花Lonicera japonica水提物中的化学成分。方法利用D101、Sephadex LH-20、硅胶等各种柱色谱法进行分离纯化,通过波谱分析手段(IR、UV、NMR等)及化合物的理化性质进行结构鉴定。结果从金银花水提物中分离得到7个裂环环烯醚萜苷类化合物,分别为:vogeloside(Ⅰ)、7-epi-vogeloside(Ⅱ)、secologanicacid(Ⅲ)、sweroside(Ⅳ)、secoxyloganin(Ⅴ)、secologanoside(Ⅵ)、(E)-aldosecologanin(Ⅶ)。结论其中化合物Ⅲ和Ⅵ为首次从忍冬属植物中分离得到,化合物Ⅶ为迄今为止较为罕见的通过碳碳键相连的二聚体环烯醚萜苷。Objective To study the constituents in water-extracts from Flos Lonicerae. Methods Compounds were isolated and purified by using various column chromatography such as D101, Sephadex LH-20, and silica gel, etc. Their structures were identified on the basis of physical and spectral data. Results Seven secoiridoid glycosides were obtained and identified as vogeloside （ Ⅰ ）, 7-epi-vogeloside （ Ⅱ ）, secologanic acid （ Ⅲ ）, sweroside （Ⅳ）, secoxyloganin （ Ⅴ ）, secologanoside （ Ⅵ ）, （E）-aldosecologanin （Ⅶ）. Conclusion Among them, compounds Ⅲ and Ⅵ are firstly obtained from the plants in Lonicera L. The structure of compound Ⅶ is rare in nature so far.

关 键 词：金银花 裂环环烯醚萜苷secologanic ACID secologanoside 

分 类 号：R284.1[医药卫生—中药学]