原发性高血压胰岛素抵抗与红细胞胰岛素受体的关系  

Insulin Resistance and Erythrocyte Insulin Receptors in Essential Hypertension

作　　者：潘雷[1] 杨尚印[1] 俞国华 严文魁 

机构地区：[1]皖南医学院附属医院

出　　处：《高血压杂志》1997年第2期125-127,共3页Chinese Journal of Hypertension

摘　　要：目的探讨胰岛素受体和胰岛素敏感性指数之间的关系。方法用改良Ｇａｍｂｈａｉｒ法检测定３７例原发性高血压患者和１３例正常人的红细胞胰岛素受体，并以胰岛素敏感性指标作对照。结果高血压患者的红细胞胰岛素受体明显降低，和胰岛素敏感指数之间呈明显的负相关，而健康人的两者之间呈明显的正相关。结论高血压患者的胰岛素受体的减少在胰岛素抵抗发病上起重要作用。Aim\ To investigate the relationship between the insulin resistance and the function of erythrocyte receptor of insulin in hypertensive subjects.\ Methods\ Erythrocyte insulin receptor(EIR) were determined using modified Gambhair's methodin 37 patients with moderate essential hypertension and 13 matched normal controls.Insulin resistance index was assessed by fasting insulin times fasting blood glucose level.\ Results\ The numbers of EIR were less in hypertension group than that in control group( P <0.01). Negative linear correlation between EIR and insulin resistance index was found in patients of hypertension, but a positive correlation was shown in normal controls.\ Conclusion\ Decreases in insulin receptor may play an important role in etiology of insulin resistance.

关 键 词：胰岛素抵抗 红细胞 受体 高血压 胰岛素受体 

分 类 号：R544.102[医药卫生—心血管疾病]