中药对小儿反复呼吸道感染免疫干预的研究  

Effects of immunotherapy with infantile recurrent respiratory tract infection by Chinese materia medica

作　　者：胡国华[1] 王井和 姚静婵[1] 史训统 

机构地区：[1]金华职业技术学院医学院儿科,浙江金华321000 [2]浙江省义鸟市中心医院,浙江义乌322000 [3]浙江省慈溪妇幼保健院,浙江慈溪315300

出　　处：《中国中药杂志》2008年第1期82-84,共3页China Journal of Chinese Materia Medica

摘　　要：目的：探讨中药对小儿反复呼吸道感染的免疫干预影响。方法：随机分为观察组和对照组,观察组采用中药,2次/天口服。对照组用口服卡慢舒,〈4岁,每次3 mL;4~7岁,每次5 mL;〉7岁,每次7 mL。每日3次。两组疗程均为8周。治疗前后两组测定血IL-12,TNF-α,IL-6,IL-13,IL-2,IL-4的变化并进行分析。结果：中药治疗后患儿的IL-12,IL-2的含量比治疗前升高。而TNF-α,IL-13,IL-4,IL-6的含量比治疗前降低。与对照组同期比较P〈0.01,观察组治疗前比较P〈0.01。随访1年,观察组临床呼吸道感染年均次数明显减少,与对照组比差异有显著性（P〈0.01）。结论：中药能有效干预儿童反复呼吸道感染,增强儿童的抗病能力。Objective： To explore the effect of Chinese materia medica on immune intervention of infantile recurrent respiratory tract infection.Method： Thirty-one children of recurrent respiratory tract infection were randomly divided into two groups： therapy group was treated with oral Chinese materia medica（b.i.d）,control group was only treated with oral carboxymethyl liquor（〈4 years,3 mL;4-7 years,5 mL;〉7 years, 7 mL,t.i.d）.The change of IL-12,TNF-α,IL-6,IL-13,IL-6 and IL-4 in different time were observed and analyzes.Result： Compared with the control group,the level of IL-12 and IL-2 was significantly increased after treatment of oral Chinese materia medica（P〈0.01）,however,the level of TNF-α,IL-13,IL-4,and IL-6 was decreased after treatment（P〈0.01）.During one years＇ follow-up study,the frequency of respiratory infection every year of therapy group was significantly decreased than that of control group.Conclusion： Chinese materia medica could prevent infantile recurrent respiratory tract infection effectively,increase humoral immunity function and ensure normal growth in children.

关 键 词：反复呼吸道感染 儿童 中药 卡慢舒 免疫干预 辅助性细胞(TH) 

分 类 号：R272[医药卫生—中医儿科学]