妊高征患者血浆D-二聚体的检测及临床意义  

Determination of Plasma D dimer in Patients with Pregnancy Induced Hypertension

作　　者：周华友[1] 陈蓉[1] 刘希平[1] 周建跃[1] 

机构地区：[1]福建省三明市第一医院妇产科

出　　处：《中华妇产科杂志》1997年第6期347-349,共3页Chinese Journal of Obstetrics and Gynecology

摘　　要：目的：探讨妊高征患者和正常妊娠妇女血浆Ｄ－二聚体的变化及临床意义。方法：用酶联免疫吸附试验，定量检测１０６例正常妊娠妇女（正常妊娠组）和５４例妊高征患者（妊高征组，其中轻、中度妊高征２５例，先兆子痫１８例，子痫１１例）血浆Ｄ－二聚体。结果：轻、中度妊高征患者血浆Ｄ－二聚体水平为２．２７±０．９２ｍｇ／Ｌ，显著高于正常妊娠组晚孕期（１．４５±０．３８ｍｇ／Ｌ，Ｐ＜０．０１）；先兆子痫患者血浆Ｄ－二聚体水平为３．０９±１．６５ｍｇ／Ｌ，显著高于轻、中度妊高征患者（Ｐ＜０．０１）；子痫患者血浆Ｄ－二聚体水平为５．６２±１．３４ｍｇ／Ｌ，显著高于先兆子痫患者（Ｐ＜０．０１）。结论：临床上动态检测中、晚孕期妊娠妇女血浆Ｄ－二聚体水平对妊高征的早期诊断有重要意义；监测妊高征患者血浆Ｄ－二聚体水平可预测疾病的预后。Objective: To investigate the changes and the clinical significance of plasma D dimer in normal pregnant women and patients with pregnancy induced hypertension (PIH). Methods: Using ELISA method, we measured the level of plasma D dimer in 160 cases, including 106 normal pregnant women and 25 patients with mild and moderate PIH, 18 patients with preeclampsia and 11 patients with eclampsia. Results: The value (2.27±0.92 mg/L) of plasma D dimer in mild and moderate PIH patients was markedly higher than that of normal third trimester pregnant women (1.45±0.38 mg/L, P <0.01). The value (3.09±1.65 mg/L) of plasma D dimer in preeclampsia patients was markedly higher than that of mild and moderate PIH patients ( P <0.01). The value (5.62±1.34 mg/L) of plasma D dimer in eclampsia patients was markedly higher than that of preeclampsia patients. Conclusion: Determination of plasma D dimer level in second and third trimester pregnant women was of great significance in diagnosing early PIH and predicting the prognosis of PIH.

关 键 词：妊娠并发症 高血压 D-二聚体 综合征 

分 类 号：R714.253[医药卫生—妇产科学] R714.246[医药卫生—临床医学]