3-甲基-4-氨基-1，2，4-三唑-5-硫酮席夫碱的合成及生物活性研究  

Synthesis and Biological Activities of 4,5-Dihydro-3-methyl-4-amino- 1,2,4-triazole-5-thione Schiff Bases

作　　者：孙晓红[1] 陶燕[1] 刘源发[2] 贾婴琦[2] 陈邦[2] 

机构地区：[1]西北大学化工学院化学研究所,西安710069 [2]西北大学化学系,西安710069

出　　处：《化学学报》2008年第2期234-238,共5页Acta Chimica Sinica

基　　金：陕西省自然科学基金(No．2001H11);西北大学科研启动基金

摘　　要：用自制的二氨基硫脲与乙酸反应得到3-甲基-4-氨基-1，2，4-三唑-5-硫酮，然后以醋酸为反应溶剂和催化剂，使之与取代芳香醛反应，合成了8个三唑类席夫碱化合物，通过^1H NMR，IR和元素分析对所有化合物进行了结构表征．并对这些化合物进行了初步生物活性测试，结果表明大部分化合物具有较好的抑菌活性，并对席夫碱结构与活性的关系进行了探讨。Thiocarbazide was reacted with acetic acid to prepare 4,5-dihydro-3-methyl-4-amino-1,2, 4-triazole-5-thione. Then eight Schiff bases were synthesized using this 1,2,4-triazole-5-thione and substituted aromatic aldehydes as starting materials, with acetic acid as a catalyst and solvent. The structures of all the compounds have been confirmed by ^1H NMR, IR and elemental analysis. Their biological activities to several vegetable pathogens have been tested and the results showed that they exhibited good fungicidal activities.

关 键 词：席夫碱 三唑硫酮 合成 生物活性 

分 类 号：O626.2[理学—有机化学]