含哌嗪取代酞菁金属配合物的合成及其对癌细胞的光灭活作用  

Metal Phthalocyanines Piperazine Containing:Synthesis and Photoinhibition on Cancer Cell

作　　者：黄紫洋[1] 黄剑东[1] 陈锦灿[2] 陈耐生[1] 黄金陵[1] 

机构地区：[1]福州大学功能材料研究所 [2]中国科学院福建物质结构研究所,福州350002

出　　处：《无机化学学报》2008年第1期55-60,共6页Chinese Journal of Inorganic Chemistry

基　　金：国家自然科学基金(No.20201005);福建省自然科学基金(No.E0513011)

摘　　要：本文报道了8种含哌嗪取代酞菁金属配合物{(SPEO)4PcM,M=Zn、Ni、Co、Cu,SPEO=2-[4-(2-磺基乙基)哌嗪-1-基]乙氧基}的合成及其表征,并分别测定了它们的紫外可见吸收光谱、荧光发射光谱、DPBF捕获单线态氧的能力,结果表明它们都具有极高的摩尔消光系数、较高的荧光量子产率、较大的单线态氧生成速率。通过对肝癌细胞BEL7402光灭活作用的研究发现,当β-(SPEO)4PcZn浓度为10μmol.L-1时,在670nm激光辐照下,光剂量为1.2J,药物对癌细胞的抑制率可达82%。The synthesis and characterizations of eight metal phthalocyanines containing piperazine（SPEO）4PcM,where M=Zn,Ni,Co or Cu,SPEO=2-[4-（2-sulfonic ethyl）piperazine-1-yl] ethyoxyl were studied.The UV-Vis absorption spectra,fluorescence emission spectra and capacity of singlet oxygen yield with DPBF as capturer were examined.The results show that all complexes possess very high molar extinction coefficient,fluorescence quantum yield,rate of singlet oxygen yield.Zinc phthalocyanine complex β-（SPEO）4PcZn possesses the best photoinhibition through photodynamic inhibition of BEL7402 liver cancer cells,82% cancer cells are inhibited after it is irradiated by 1.2 J photo dosage of 670 nm red-light laser when the concentration of β-（SPEO）4PcZn with 10 μmol·L^-1 is used.

关 键 词：酞菁金属配合物 HEPES 合成 光灭活作用 

分 类 号：O611.4[理学—无机化学] R979.1[理学—化学]