甘精胰岛素联合阿卡波糖治疗2型糖尿病临床观察  

Clinical observation on insulin glargine combined with acarbose treating type 2 diabetes mellitus

作　　者：权晓娟[1] 王妮[1] 付淑丽[1] 李荣[1] 张莹[1] 

机构地区：[1]西安交通大学医学院第二附属医院干部病区,陕西西安710004

出　　处：《第四军医大学学报》2008年第3期283-285,共3页Journal of the Fourth Military Medical University

摘　　要：目的:探讨睡前皮下注射长效重组甘精胰岛素与睡前皮下注射中效低糖蛋白锌人胰岛素(诺和灵N)联合口服阿卡波糖治疗2型糖尿病的疗效比较.方法:将90例口服降糖药血糖控制不理想的2型糖尿病患者随机分为甘精胰岛素治疗组和诺和灵N治疗组.比较治疗后两组日平均血糖、血糖达标时间、低血糖事件发生率、空腹血糖达标时每日所用甘精胰岛素和诺和灵N的剂量、空腹C肽及平均空腹血糖(FBG)、糖化血红蛋白(HbA1c)、体质量指数(BMI).结果:甘精胰岛素组在日平均血糖、血糖达标时间、低血糖发生率、每日应用胰岛素的剂量方面均低于诺和灵N组,差异有统计学意义(P<0.05).两组治疗后空腹血糖、糖化血红蛋白、体质量指数方面差异无统计学意义(P>0.05).结论:糖尿病患者应用甘精胰岛素联合口服阿卡波糖治疗降血糖效果更好,安全性更高.AIM： To study the treatment effect of insulin glargine and neutral protamine hadegorn （NPH） given by hype on bedtime combined with acarbose for type 2 diabetes mellitus. METHODS： Ninety cases of type 2 diabetic patients taking oral anti-diabetic drugs with poor blood glucose （BG） were divided into 2 groups （glargine group and NPH group） at random. The 2 groups were compared in the mean level of BG, the time to reach the target BG, the incidence rate of the hypoglycemia, the requirement of glargine and NPH to reach the target fast blood glucose （FBG）, the level of the C peptide, the mean FBG, the HbAlc and body mass index （BMI） after treatment. RESULTS： The mean BG level, the time to reach the target BG, the incidence rate of hypoglycemia and the requirement of insulin in glargine group were obviously lower than those in NPH group （P〈0.05）. The FBG, HbAlc and BMI of the two groups were similar （P 〉 0.05 ）. CONCLUSION： It is more effective and safer for diabetic patients to use insulin glargine combined with acarbese to decrease BG.

关 键 词：胰岛素 阿卡波糖 糖尿病 

分 类 号：R587.1[医药卫生—内分泌]