HLA-DRB1、HLA-DRB3、HLA-DRB4、HLA-DRB5与HLA-DQ位点不关联病例的研究  

Research about the disassociated cases between HLA-DRB1、HLA-DRB3、HLA-DRB4、HLA-DRB5 locus and HLA-DQ locus

作　　者：赵丹丹[1] 孙敬芬[1] 朱海燕[1] 韩晓苹[1] 金荔[2] 刘楠[2] 奚永志[2] 高春纪[1] 于力[1] 

机构地区：[1]解放军总医院血液科,北京100853 [2]军事医学科学院附属医院免疫室,北京100039

出　　处：《军医进修学院学报》2008年第1期58-60,共3页Academic Journal of Pla Postgraduate Medical School

摘　　要：目的：完善目前已知的HLA-DR与HLA-DQ关联表。方法：从2000-2006年间到我们实验室配型的供患者中选出与关联表不相符的16例标本并对这些标本进行高分辨鉴定。结果：发现在中国汉族人中的五条HLA-DR与HLA-DQ位点连锁遗传的单倍体。结论：为目前所用的HLA-DR与HLA-DQ位点关联表在中国人群中增加五个新的单倍体，使关联表更适合于中国人群。Objective： to complement the known HLA-DR and HLA-DQ linkage table. Methods： 16 cases were found from patient and donor samples during 2000-2006 whose HLA-DR locus were not normally linkage disequilibrium with HLA-DQ locus and analyzed them with high resolution of PCR-SSP. Resets： We found five new haplotypes in Chinese han race whose HLA-DR and HLA-DQ locus were not coincident with the previous linkage table. Conclusion：Through adding five new haplo- types to the linkage table makes the linkage table more suitable for the Chinese race.

关 键 词：HLA-DR抗原 HLA-DQ抗原 连锁不平衡 

分 类 号：R551[医药卫生—血液循环系统疾病]