灵芪蠲肝液对大鼠急慢性肝损伤影响  

THE EFFECTS AND MECHANISM OF LINGQIJUANGAN LIQUOR ON ACUTE AND CHRONIC HEPATIC INJURY IN RATS

作　　者：刘剑[1] 李万平[1] 李晓冰[1] 肖顺汉[1] 邓存良[2] 陈枫[2] 唐坤华[2] 

机构地区：[1]泸州医学院药理教研室,四川泸州646000 [2]泸州医学院附属医院传染免疫教研室,四川泸州646000

出　　处：《泸州医学院学报》2008年第1期29-31,共3页Journal of Luzhou Medical College

摘　　要：目的:研究灵芪蠲肝液对大鼠实验性急慢性肝损伤的保护作用及可能作用机制。方法:硫代乙酰胺复制急性肝损伤模型,40%的四氯化碳溶液复制慢性肝损伤模型,硝酸还原酶比色法检测一氧化氮(NO)含量以及取肝组织做病理组织学检查。结果:硫代乙酰胺急性肝损伤及四氯化碳慢性肝损伤时,灵芪蠲肝液能使血清NO水平明显降低,与模型组比较,具有统计学意义(P<0.05);病理组织学检查发现该药物能减轻肝细胞变性、坏死,减少炎细胞浸润及减轻肝脂肪变性、减少纤维组织增生、促进肝细胞再生。结论:灵芪蠲肝液具有减轻急慢性肝损伤的作用,可能与减少NO的产生有关。Objective： To study the effects and possible mechanism of Lingqijuangan Liquor on acute and chronic hepatic injury. Methods： Acute and chronic hepatic injury were induced by thioacetamide and CCI4 respective. Then the level of serum nitric oxide （NO） was detected. Liver tissue was taken to do pathological examination. Results： Compared with model group, volume of NO in homogcnates were significantly decreased by Lingqijuangan Liquor （P〈0.05）. Pathological examination result showed that Lingqijuangan Liquor could relieve hepatic cell denaturation and putrescence, also reduce inflammation cell infiltration. Conclusion： Lingqijuangan Liquor can relieve the experimental acute and chronic hepatic injury. The mechenism may be related to reducing the production of NO.

关 键 词：灵芪蠲肝液 急性肝损伤 慢性肝损伤 大鼠 一氧化氮 

分 类 号：R961[医药卫生—药理学]