小儿先天性心脏病心房利钠肽、脑利钠肽、内皮素-1水平的研究  

Study ANP,BNP and ET-1 level in children with congenital heart diseases (CHD) at Pre- and post- interventional therapy

作　　者：王新卫 伍伟锋[2] 俸勇强 唐沙玲 蒋福明 

机构地区：[1]桂林市妇女儿童医院急诊科,广西541001 [2]广西医科大学第一附属医院心内科

出　　处：《中国心血管病研究》2008年第2期87-89,共3页Chinese Journal of Cardiovascular Research

基　　金：广西科技攻关项目(桂科攻0472002-30)

摘　　要：目的观察先天性心脏病(先心病)介入封堵术前后的心房利钠肽(ANP)、脑利钠肽(BNP)、内皮素-1(ET-1)的变化,探讨先心病ANP、BNP和ET-1的激活状况及其临床意义。方法检测70例先心病患者的ANP、BNP和ET-1水平,另选取年龄及性别与之相匹配的正常体检儿童30例作为对照组。结果先心病血循环中的ANP(25.6±7.5)pmol/L、BNP(15.7±7.4)pmol/L、ET-1(1.12±0.31)pmol/L与对照组比较明显增高(均P=0.0001)。根据NYHA心功能分级,3个亚组随着疾病严重程度的加重,ANP、BNP、ET-1的激活就越明显。结论先心病患者存在着ANP、BNP和ET-1的明显激活并具有慢性心力衰竭的特征,并与疾病的严重性关系密切。Objective To detect the level of ANP,BNP and ET-1, and explore whether ANP,BNP and ET-1 activation exists in children with congenital heart disease. Methods Concentrations of atrial natriuretic peptide （ANP）, brain natriuretic peptide （BNP） and endothelin-l（ET-1 ） were determined in 100 children with congenital heart disease. Results Children with congenital heart disease had elevated levels of ANP （25.6±7.5） pmol/L, BNP（15.7±7.4）pmol/L, ET-1 （1.12±0.31）pmol/L（all P=0.0001）. There was a highly significant stepwise increase in ANP, BNP, ET-1 according to New York Heart Association class, with even asymptomatic patients having evidence of significant neurohormonal activation. Conclusion ANP,BNP and ET-1 activation in children congenital heart disease bears the hallmarks of chronic heart failure, relating to symptom severity and ventricular dysfunction.

关 键 词：心脏病/先天性 心钠素 利钠肽 脑 内皮素-1 

分 类 号：R541[医药卫生—心血管疾病]