液压脑损伤大鼠大脑皮质突触素的动态变化  

Kinesis Change of Synaptophysin in Ceretral Cortex of Hydraumatic Brain Injured Rats

作　　者：李雪峰[1] 刘绍明[2] 闫志强[2] 李建[1] 

机构地区：[1]石河子大学医学院 [2]兰州军区乌鲁木齐总医院神经外科,新疆乌鲁木齐830000

出　　处：《现代生物医学进展》2008年第2期225-228,共4页Progress in Modern Biomedicine

基　　金：兰州军区资助科研课题(LXH-2007010)

摘　　要：目的:探讨液压脑损伤后突触素在皮质区表达的动态变化。方法:应用液压脑损伤复制脑损伤动物模型,应用免疫组织化学和计算机图像分析技术定量分析皮质受损区突触素表达的动态变化,结果:突触素在皮质受伤区表达呈现两次高峰:分别为3～12h和15～30d,90d表达接近正常:结论:突触素在皮质受伤区第2次表达增高可能与脑的结构和功能恢复有关。急性期表达增高则可能与脑的直接损伤有关。Objective： To investigate the expression changes and the progression of immunoreactivity of synaptophysin in the cerebral cortex after fluid percussion brain injury. Methods： Rats were given a fluid percussion brain injury and the changes of synaptophysin at different times after fluid percussion brain injury were detected quantitatively with immunohistoehemistry and computerized image analysis. Results： Synaptophysin immunoreactivity presented two peaks after fluid percussion brain injury in the cerebral cortex. Transient increase was observed during （3-12） h, A second peak was observed at （15-30） d and synaptophysin immunoreactivity decrease to normal on 90 days after fluid percussion brain injury, Conclusion： The second increased expression of synaptophysin in the cerebral cortex concerned with recovery of constitution and function in the cerebral cortex, The early increase of expression of synaptophysin might be involved in the directly traumatic brain injury in the cerebral cortex.

关 键 词：突触素 大脑皮质 创伤性脑损伤 液压冲击 

分 类 号：R651.1[医药卫生—外科学]