阿托伐他汀治疗急性冠状动脉综合症的疗效分析  

Effect of Atorvastatin in Treatment of Patients with Acute Coronary Syndromes

作　　者：杨娇妹 曾德明[1] 

机构地区：[1]湖南武冈市人民医院内一科,武冈422400

出　　处：《现代生物医学进展》2008年第2期317-320,共4页Progress in Modern Biomedicine

摘　　要：目的:探讨不同剂量的阿托伐他汀治疗急性冠状动脉综合症的疗效,并探讨患者性别与年龄对疗效的影响。方法:240例急性冠状动脉综合症患者随机分为常规治疗组(60例)和阿托伐他汀治疗组(180例),其中阿托伐他汀治疗组又分为20mg/d、40mg/d和80mg/d三组,每组60例。常规治疗组采用拜阿司匹林、硝酸酯类、血管紧张素转换酶抑制剂等,阿托伐他汀组在常规治疗基础上加用阿托伐他汀;疗程8周。检测患者治疗前后的hs-CRP、TC、TG、LDL-C和HDL-C的水平的变化。选取60例健康人作为对照组。结果:与正常组或常规治疗组相比,急性冠状动脉综合症患者治疗8周后,阿托伐他汀组中患者的hs-CRP、TC、TG、LDL-C和HDL-C的水平变化差异均有统计学意义(P<0.05)。在三个使用剂量中,以剂量为40mg/d的阿托伐他汀治疗组的治疗效果相对最好(P<0.05)。急性冠状动脉综合症患者的发病的风险度/程度与患者年龄的呈正相关,但与患者性别无明显相关;而治疗效果与年龄基本呈负相关。结论:40mg/d剂量的阿托伐他汀治疗早期ACS可获得较好的疗效。Objective： To investigate the therapeutic effect of the acute coronary syndromes by the different doses atorvastatin, and analyse the influence in different sexes and ages patients. Method： Two hundred and forty acute coronary syndromes cases were divided two groups by random method. There were sixty acute coronary syndromes patients in the fist group, and they were treated by the conventional therapy method and cure medicines included Aspirin, nitrate, angiotensin converting enzyme inhibitor and so on. The other group included 180 acute coronary syndromes patients, and then theye were divided to three sub-group treated by 20mg/d, 40mg/d and 80mg/d atorvastatin respectively, 60 cases/every sub-group. The three sub-groups were treated by the conventional therapy method and the different dose atorvastatin in addition. After eight weeks, we detected the lever of the hs-CRP, TC,TG, LDL-C and HDL-C of patients before and after therapy. Sixty healthy adults were as the control. Results： Compared with the control group and the conventional therapy group, the changes of the hs-CRP, TC, TG,LDL-C and HDL-C level in the three sub-groups were statistical significance （P〈0.05） after eight weeks cure. The sub-group which were treated 40 mg/d atorvastatin gained the best therapeutic efficacy compared with the other sub-groups （P〈0.05）. The invasive rate of the acute coronary syndromes had positive correlation with the age of the patients, and had no an obviously correlation with the sex of the patients. The therapeutic efficacy had negative correlation with the age of the patients. Conclusion： Atorvastatin is an efficacious medicine for acute coronary syndromes therapy, and it work well in 40 mg/d dose.

关 键 词：阿托伐他汀 急性冠状动脉综合症 HS-CRP 

分 类 号：R541.4[医药卫生—心血管疾病] R542.2[医药卫生—内科学]