分泌囊泡启动步骤和相关调节蛋白研究进展  

Research Progress on Priming Steps of Secretory Vesicles and Related Regulative Proteins

作　　者：朱丹[1] 

机构地区：[1]华中科技大学生命科学与技术学院,湖北武汉430074

出　　处：《现代生物医学进展》2008年第2期386-389,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金(30630020;30670502)

摘　　要：囊泡启动是细胞调节性分泌中非常关键的一个步骤,囊泡启动后才具备与膜融合的能力。囊泡的启动过程需要SNARE复合体的形成和许多其它蛋白如Munc13、RIM、CAPS等的参与,但不同类型的分泌囊泡其关键的启动因子并不相同。本文主要从分泌囊泡的启动过程和不同囊泡所特异的启动因子着手,综述了囊泡转运过程中启动步骤的最新研究进展。Objective Vesicle priming is one of the crucial steps in the cellular regulative secretion. Only after priming, vesicles have the ability of membrane fusion. The priming process of vesicles needs the complex formation of SNARE and the participation of many other proteins,such as Munc 13, RIM, and CAPS. But different types of secretory vesicles have different key priming factors. In this article, beginning with the priming process of secretory vesicles and different kinds of vesicles with specific priming factors, research progress of priming steps in the transport process of vesicles has been reviewed.

关 键 词：分泌囊泡 启动 SNARE Munc13 CAPS 

分 类 号：Q813[生物学—生物工程]