L-酒石酸异丁酯的合成  

Synthesis of isobutyl L-tartrate

作　　者：黄灵芝[1] 李丽峰[1] 黄朋勉[1] 董君英[1] 

机构地区：[1]长沙理工大学化学与环境工程学院,湖南长沙410076

出　　处：《长沙理工大学学报（自然科学版）》2007年第4期91-93,共3页Journal of Changsha University of Science and Technology:Natural Science

基　　金：湖南省自然科学基金资助项目(06JJ30005)

摘　　要：以L-酒石酸、异丁醇为原料合成了手性拆分试剂L-酒石酸异丁酯.考察了带水剂用量、醇酸摩尔比、催化剂种类、催化剂用量对产品酯化率的影响.研究结果表明,最好的催化剂为对甲苯磺酸,在醇酸摩尔比为3∶1,催化剂的最佳用量为1 g,带水剂甲苯用量为60 mL的条件下,L-酒石酸异丁酯的酯化率可达99.4%.A chiral resolving reagent isobutyl L-tartrate was prepared from L-tartaric acid and isobutyl alcohol using p-toluene sulphonic acid and toluene as a catalyst and a water-carrying agent,respectively.The influence such as the amount of water-carrying agent,molar ratio of isobutyl alcohol to L-tartaric acid and the amount of catalyst on the yield of isobutyl L-tartrate were discussed.The results show that p-toluene sulphonic acid be a good catalyst for synthesizing isobutyl L-tartrate.The yield of isobutyl L-tartrate was up to 99.4% when molar ratio of isobutyl alcohol to L-tartaric acid was 3∶1,amount of catalyst was 1 g,water-carrying agent toluene was 60 mL.

关 键 词：L-酒石酸 异丁醇 L-酒石酸异丁酯 合成 

分 类 号：O632.1[理学—高分子化学]