新生儿肠道病毒医院感染28例分析  

Neonatal Enterovirus Nosocomial Infection:An Analysis of 28 Cases

作　　者：韩彤妍[1] 朴梅花[1] 童笑梅[1] 张艳志 刘惠丽[1] 郑粤吟[1] 李松[1] 叶鸿瑁[1] 

机构地区：[1]北京大学第三医院儿科,北京100083 [2]陕西省建材医院儿科,陕西西安710043

出　　处：《中华医院感染学杂志》2008年第2期212-214,共3页Chinese Journal of Nosocomiology

摘　　要：目的分析2006年夏季肠道病毒医院感染的临床特点及暴发流行严重程度。方法聚合酶链反应法(PCR)进行病原学检测,对28例肠道病毒医院感染新生儿病例进行回顾性分析,总结临床症状、病情轻重及转归。结果此次肠道病毒医院感染暴发流行持续>1个月,医院感染发生率达6.4%;22例(78.6%)的患儿首发症状为发热;14例(50.0%)静脉血/脑脊液检测到肠道病毒,根据接触史、临床症状等,28例临床诊断为肠道病毒感染,其中10例(35.7%)为病毒性脑膜炎,9例(32.1%)新生儿肺炎,1例(3.6%)肝脏损害,2例(7.1%)心肌损害,全部患儿均好转或治愈出院。结论此次发生于夏季的肠道病毒医院感染病情相对轻,临床经过良好,经治疗避免了医院感染暴发流行。OBJECTIVE To analyze 28 cases in an outbreak of neonatal enterovirus nosocomial infection during summer of 2006. METHODS Demographic characteristics, clinical manifestations, laboratory data and outcome were analyzed to reveal the clinical severity. RESULTS The outbreak lasted more than one month and the nosocomial infection rate increased to 6.4%0. There were 22 cases （78.6%0） first presented with fever. Half of the patients were detected enterovirus from blood or cerebrospinal fluid by PCR. All of the 28 cases were diagnosed enterovirus infection based on the contact history, clinical signs and laboratory results. Among them, ten cases had viral meningitis. All patients discharged home after hospitalization with no sequelae, CONCLUSIONS Although this group of neonatal enterovirus infection developed viral meningitis, they had relatively mild illness with benign clinical course. Extreme vigilance is required in interrupting the spread of nosocomial enterovirus infections in neonatal units. This includes respect of strict hygiene measures and meticulous hand-washing.

关 键 词：肠道病毒 新生儿 医院感染 

分 类 号：R181.32[医药卫生—流行病学]