肝炎治疗药苦参碱葡萄糖注射液的研制  

Preparation of Matrine and Glucose Injection for Hepatitis Therapeutic Drug

作　　者：杨善彬[1,2] 梅虎[1] 张梦军[3] 李志良[1] 

机构地区：[1]重庆大学生物工程学院生物医学工程教育部与重庆市重点实验室,重庆400044 [2]宜宾学院生物制药研究所,宜宾644000 [3]第三军医大学医学检验系,重庆400040

出　　处：《天然产物研究与开发》2007年第B08期333-336,共4页Natural Product Research and Development

基　　金：宜宾学院青年科研基金（2003Q18）;重庆市应用基础基金（01-3-6）;第三军医大学青年教师自主创新基金（批准号：05-5-28）

摘　　要：为研制供临床直接使用的大容量苦参碱葡萄糖注射液，采用苦参碱浓配，葡萄糖先浓配除热原、后稀配混合苦参碱溶液、精滤、灌封、灭菌等制得苦参碱葡萄糖注射液，并建立质量标准。结果表明：试制3批样品均符合质量标准要求，稳定性考察未见明显变化。研制的苦参碱葡萄糖注射液处方及工艺合理可行、质量标准可控、稳定性良好。To study the preparation of matrine and glucose injection for clinic use, the injection is prepared by diluting matfine and glucose with injeetion water in high concentration first, after the pyragen is diseovered, diluting the mixture to the labeled concentration, then filtering the mixture with 0.22μm membranee filter, filling into bottle, and finally sterilizing with steam at 115℃/30 min. Three batch of samples are prepared to meet the quality standard built by ourselves, and to have no observable changes in stability test. The preseription and process of making matfine and glucose injection is practicable. The quality standard of the injection is controllable with good stability.

关 键 词：苦参碱 大容量注射液 苦参碱葡萄糖注射液 质量标准 稳定性考察 

分 类 号：R285.5[医药卫生—中药学]