紫绀型心脏病动物模型的建立  

The Development of an Animal Model of Cyanotic Heart Diseases

作　　者：许耀强[1] 刘迎龙[1] 

机构地区：[1]中国医学科学院中国协和医科大学阜外心血管病医院心血管病研究所心外科,北京100037

出　　处：《中国胸心血管外科临床杂志》2008年第1期56-59,共4页Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

基　　金：北京自然科学基金资助项目(7072049)~~

摘　　要：紫绀型心脏病是先天性心脏病研究中的重点和难点,建立这类疾病的动物模型和对其深入研究有助于推动临床诊治水平的不断提高。已知的方法包括人造肺动-静脉瘘法、下腔静脉-左心房转流法、主肺动脉-左心房分流法、非手术操作的低氧吸入法等。紫绀型心脏病动物模型的建立经过了不断地改良和改进,成为研究紫绀缺氧状态下病理生理的重要工具和手段,但总体来讲仍未十分成熟和完善,需要继续探索和研究。The cyanotic congenital heart defect remains a focal point to study in congenital heart diseases. A successfully developed model of cyanotic congenital heart defect can contribute to a profound advancement of clinical diagnosis and treatment. Various kinds of animal models simulating cyanotic heart diseases have been created and improved step by step, such as experimental pulmonary arteriovenous fistulas, inferior vena cava-left atrium shunt, pulmonary artery-left atrium shunt and breeding animals in mionectic environment. As an important means, they are used to investigate the animal＇s pathophysilolgocal characteristics in cyanotic and hypoxic state. However, it need a further exploration since these models are not fully perfect yet.

关 键 词：动物模型 心脏缺损 先天性 紫绀 

分 类 号：R541[医药卫生—心血管疾病] R-332[医药卫生—内科学]