急性心肌梗死患者冠脉介入手术前后血清中缺血修饰白蛋白水平的变化及临床意义  

Variance of Serum Ischemia Modified Albumin in Acute Myocardial Infarction Patients before and after Percutaneous Coronary Intervention and Its Clinical Significance

作　　者：黄山[1] 邓小林[1] 周晓泉[1] 刘志琴[2] 

机构地区：[1]贵州省临床检验中心,贵阳550002 [2]贵州省人民医院心内科

出　　处：《微循环学杂志》2008年第1期33-34,共2页Chinese Journal of Microcirculation

基　　金：贵州省优秀教育人才省长专项资金项目[黔省专合字(2006)68号]

摘　　要：目的:比较急性心肌梗死(AMI)患者行冠脉介入术(PCI)前后血清中缺血修饰白蛋白(IMA)水平的变化,探讨IMA的形成机制及其对心肌缺血早期诊断和疗效观察的临床意义。方法:采用白蛋白钴结合(ACB)试验分别测定对照组和AMI患者PCI前及PCI后不同时间段血清IMA水平。结果:心肌缺血引起血清IMA急性升高(P<0.05),术后3h回复到术前水平,术后6h～30h血清IMA与术前比较显著降低(P<0.05)。结论:心肌缺血可造成AMI患者血中IMA急性升高;PCI可有效改善心肌缺血状况。IMA可作为心肌缺血早期诊断和疗效观察的重要指标。Objective:To compare variance of serum ischemia modified albumin in acute myocardial infarction(AMI)patients before and after percutaneous coronary intervention,and to explore the formation mechanism of serum ischemia modified albumin and its clinical significance in the early diagnosis and treatment of myocardial ischemia.Method:Albumin cobalt binding(ACB)test was used to determine the serum ischemia modified albumin level in different periods before and after percutaneous coronary intervention both in the controlled group and the acute myocardial infarction patients.Results:Myocardial ischemia could cause the increase of ischemia myocardial albumin promptly(P<0.05),which could return to the same level 3 hours after operation.The ischemia myocardial albumin level decreased significantly 6-12 hours after operation compared with pre-operation(P<0.05).Conclusion:Myocardial ischemia can cause the acute increase of ischemia modified albumin in acute myocardial infarction patients,and percutaneous coronary intervention can improve the condition of myocardial ischemia,which infers that ischemia modified albumin can be used as one of the important indicators in the early diagnosis and treatment of myocardial ischemia patients.

关 键 词：急性心肌梗死 急性心肌缺血 临床意义 心肌梗死患者 蛋白水平 冠脉介入 后血清 手术前 

分 类 号：R542.22[医药卫生—心血管疾病] R542.2[医药卫生—内科学]