2型糖尿病合并周围神经病变与瘦素、白细胞介素-6、C-反应蛋白关系的探讨  

Relationship between serum Leptin, Interleukin-6, C-reactive protein and peripheral neuropathy disease in patients with type 2 diabetes

作　　者：周海燕[1] 于丽萍[1] 谢晓敏[1] 李仁达[1] 张丽[1] 曾斌[1] 李玲[1] 刘惠莉[1] 史静[1] 牛旭东[1] 侯庆宁[1] 邹晓燕[1] 

机构地区：[1]宁夏医学院第二附属医院内分泌科,银川750001

出　　处：《中国综合临床》2008年第2期117-119,共3页Clinical Medicine of China

基　　金：宁夏科技攻关项目（05GG-20710）

摘　　要：目的探讨2型糖尿病合并周围神经病变与瘦素（LEP）、白细胞介素-6（IL-6）、C-反应蛋白（CRP）的关系。方法选择我院住院2型糖尿病患者99例，其中单纯2型糖尿病60例（A组），2型糖尿病合并周围神经病变39例（B组），2组均进行下肢振动觉定量检测；并设正常对照50例（c组）。以上3组均测定相应生化指标，结合年龄、病程等进行分析。结果①B组病程、血清总胆固醇、明显高于A组、c组，差异有统计学意义（P〈0．01，P〈0．05）。②A组、B组LEP、IL-6、CRP明显高于C组（P〈0．01，P〈0．05）；B组LEP、IL．6和CRP显著高于A组（P〈0．01，P〈0．05）。结论2型糖尿病周围神经病变患者瘦素及炎症因子均增高。对于2型糖尿病病程长、血脂紊乱的患者应及早检测LEP、IL-6、CRP水平，有助于早期预防2型糖尿病合并周围神经病变的发生发展。Objective To investigate the association between Leptin （ LEP）, Interleukin-6 （ IL-6 ）, C-reactive protein（CRP） and peripheral neuropathy disease （PND） in patients with type 2 diabetes. Methods 99 type 2 diabetes patients of which 60 type 2 diabetes patients were with peripheral neuropathy disease （ group A） ,39 patients were with peripheral neuropathy disease （ group B）, and 50 cases were taken as control （ group C ）. Group A and Group B were tested for vibration sense. Biothesiometry of all of the above three groups were tested in combination with age and disease course. Results （1）The duration of diabetes and Tc were significantly increased in patients with PND compared with patients without PND and the normal control group （ P 〈 0.01, P 〈 0.05 ）. （2）In patients with PND and patients without PND, the serum levels of LEP, IL-6, CRP were significantly higher than the normal control group （ P 〈 0.01 ,. P 〈 0.05 ）. In patients with PND, the serum levels of LEP, IL-6, CRP were significantly higher than patients without PAD （ P 〈 0.01 P 〈 0.05 ）. Conclusion The serum levels of LEP, IL-6, CRP increase with PND in patients with type 2 diabetes. Serum levels of LEP,IL-6,CRP should be measured earlier in type 2 diabetic patients who have long-term duration of diabetes and blood lipid disorders,which may prevent the occurrence of peripheral neuroparty disease in patients with type 2 diabetes.

关 键 词：2型糖尿病 周围神经病变 瘦素 白细胞介素-6 C-反应蛋白 

分 类 号：R587.2[医药卫生—内分泌]