经肺静脉超声与射频消融对阵发性心房颤动患者血浆丙二醛和红细胞超氧化物歧化酶活性变化的影响  

The effects of radiofrequency catheter ablation and ultrasound balloon ablation on serum malondialdehyde and activity of erythrocyte superoxide dismutase in patients with paroxymal atrial fibrillation

作　　者：王健[1] 刘兴鹏[2] 刘小青[2] 马长生[2] 颜红兵[1] 

机构地区：[1]首都医科大学附属北京安贞医院抢救中心,北京100029 [2]首都医科大学附属北京安贞医院心内科,北京100029

出　　处：《中国综合临床》2008年第2期127-128,共2页Clinical Medicine of China

基　　金：北京市科技新星计划资助项目（H013610150113）

摘　　要：目的比较阵发性心房颤动经肺静脉超声球囊消融与经肺静脉射频消融对患者血浆丙二醛和红细胞超氧化物岐化酶活性的影响，为临床治疗方法的选择提供依据。方法20例阵发性心房颤动患者，10例行肺静脉超声消融治疗，10例行肺静脉射频消融治疗。分别测定2组患者术前及术后血浆丙二醛水平和红细胞超氧化物歧化酶活性。结果肺静脉超声球囊消融组术后血浆丙二醛水平和红细胞超氧化物岐化酶活性均显著低于经肺静脉射频消融组（均P〈0．05）。结论阵发性心房颤动经肺静脉超声消融治疗所造成的氧自由基损伤较经肺静脉射频消融治疗轻微、安全。Objective To study different effects of radiofrequency catheter ablation and ultrasound balloon ablation on serum malondialdehyde（MDA） and activity of erythrocyte superoxide dismutase（SOD） in patients with paroxymal atrial fibrillation. Methods 20 patients with paroxymal atrial fibrillation were equallly divided into two groups in whiich one group underwent radiofrequency catheter ablation and the other group underwent ultrasound balloon ablation. The MDA and the activity of SOD were tested in each group. Results MDA level and SOD activity were significantly lower in ultrasound balloon ablation group than in radiofrequency catheter ablation group. Conclusion The damage of oxygen free radical caused by ultrasound balloon ablation is lighter than that of radiofrequency catheter ablation, so that ultrasound balloon ablation is safer and is worth to be spread.

关 键 词：阵发性心房颤动 超声球囊消融 射频消融 丙二醛 超氧化物歧化酶 

分 类 号：R541.75[医药卫生—心血管疾病]