^(12)C^(6+)离子辐照小鼠全脑对其空间记忆的影响  

Effect of irradiation with ^(12)C^(6+ ) ions on space memory of mouse brain

作　　者：周清明[1] 张红[1] 刘阳[1] 赵卫平[1] 龙静[1] 李宁[1] 王燕玲[1] 

机构地区：[1]中国科学院近代物理研究所

出　　处：《辐射研究与辐射工艺学报》2008年第1期39-42,共4页Journal of Radiation Research and Radiation Processing

基　　金：国家自然科学基金项目(10675151);甘肃省科技攻关计划项目(2GS052-A43-008-2);甘肃省重大科技专项项目(2GS063-A43-012);兰州市-中国科学院高新技术"种子资金"项目(06-2-58)资助

摘　　要：为了研究12C6+离子辐照昆明小鼠全脑对其空间记忆的影响,采用0、0.5、1和2Gy的12C6+离子束辐照昆明小鼠全脑,用八臂迷宫测试小鼠在迷宫中的觅食速度,以及其空间记忆的变化。结果发现,辐照使小鼠的觅食速度降低,但随着训练次数的增加,受辐照组与对照组的觅食速度都提高,到训练第17天,辐照组与对照组觅食能力基本相同;辐照使小鼠的空间记忆能力短期下降,但随着时间的增加,辐照组小鼠的空间记忆能力恢复到了对照水平。以上结果提示,在0～2Gy的碳离子辐照的剂量水平,辐照在短期内影响小鼠的记忆,在一定时间后,这种影响得到恢复。In order to investigate the effect of irradiation with ^12C^6＋ ions on the space memory of the Kunming mouse, the mouse brain was irradiated with ^12C^6＋ ions at low doses of 0, 0.5, 1 and 2.0Gy respectively. It was shown that the speed of looking for baits decreased with irradiation doses and then increased with the increment of the training times while the 8-arms radial maze was tested for determination of space memory. And the speed of looking for baits in irradiated and then trained groups recovered to the control level at 17th day after irradiation. It was also found that the space memory of the mice decreased along with the irradiation dose, but recovered to the control level at 20th day after irradiation. The data suggested that the irradiation of 0 - 2Gy ^12C^6＋ ions affected the mouse space memory in a short period of time, and then it could be recovered with time gradually after the irradiation by training.

关 键 词：碳离子辐射 小鼠 空间记忆 

分 类 号：Q691.5[生物学—生物物理学]