抗癫痫“中药”中西药成分的血药浓度监测及疗效分析  

Monitoring of Serum Concentrations of Western Medicine Ingredients in "Traditional Chinese Antiepileptic Medicines" and Analysis of Curative Effects

作　　者：周琼[1] 杨龙[1] 张峻[1] 吴晖[1] 施莹[1] 

机构地区：[1]昆明医学院第一附属医院药剂科,昆明市650032

出　　处：《中国药房》2008年第5期399-400,共2页China Pharmacy

摘　　要：目的:对单用"中药"治疗的癫痫患者西药成分的血药浓度进行监测并评估其疗效。方法:对1997年2月～2006年6月在我院就诊及监测血药浓度的60例癫痫患者,于监测期间仅服用"中药"进行抗癫痫治疗后,用荧光偏振免疫分析法测定4种西药的血药浓度。结果:60例患者中,丙戊酸、卡马西平、苯妥英、苯巴比妥分别被检出18、40、41、47例/次,平均每例患者被检出含2种以上西药,绝大多数血药浓度处于有效范围以外,且总体疗效差。结论:在"中药"中检出的西药成分组方不符合癫痫的药物治疗原则,临床应谨慎对待这类抗癫痫"中药"。OBJECTIVE： To determine serum concentrations of western medicines in patients treated with “traditional Chinese antiepileptic medicine ”alone and to evaluate the curative effects.METHODS： A total of 60 epileptic patients who visited our hospital between Feb. 1997 and June 2006 were subjected to plasma drug level monitoring and during which the patients were treated with “traditional Chinese antiepileptic drugs” alone .Plasma concentrations of 4 kinds of western medicines were determined by FPIA.RESULTS： Of the 60 cases, valproic acid, carbamazepine, phenytoin and phenobarbitone were detected in 18,40,41, and 47 cases/times, respectively .On average, more than two kinds of western medicines were detected in every patient, and the blood concentrations were mostly beyond effective plasma drug concentration .The total curative effects were unsatisfactory.CONCLUSION： The fact that western medicine ingredients detected in these traditional Chinese antiepileptic medicines is inconformity with medication principle of epilepsy.Traditional Chinese antiepileptic medicines should be used with caution in the clinic in the treatment of epileptic patients.

关 键 词：抗癫痫“中药” 西药成分 血药浓度 监测 疗效 

分 类 号：R969.3[医药卫生—药理学]