子宫内膜异位症患者腹腔液和异位内膜组织MCP-1、IGF-Ⅰ水平的变化分析  

The Correlation Between the Changes of Levels of MCP-1 and IGF-Ⅰ in Peritoneal Fluid and Pathogenesis of Endometriosis and Infertility

作　　者：卢丽萍[1] 潘莉莉[1] 

机构地区：[1]中国医科大学附属盛京医院检验科,沈阳110004

出　　处：《中国医科大学学报》2008年第1期107-108,共2页Journal of China Medical University

摘　　要：目的探讨子宫内膜异位症(EM)患者腹腔液、异位内膜组织中单核细胞趋化蛋白1(MCP-1)、胰岛素样生长因子I(IGF-I)水平的变化在子宫内膜异位症发病及其在病程进展中的作用。方法观察组:EM患者30例,其中早期病例(Ⅰ～Ⅱ期)10例,晚期病例(Ⅲ期-Ⅳ期)20例;10例无内膜异位症者作为对照组。用ELISA方法测定两组腹腔液、内膜组织中MCP-1、IGF-Ⅰ含量。结果观察组腹腔液、内膜组织中MCP-1、IGF-Ⅰ水平与对照组相比较有显著差异(P<0.01),且早期病例腹腔液MCP-1及异位内膜组织MCP-1质量浓度均明显高于晚期病例,而早期病例腹腔液IGF-Ⅰ水平却明显低于晚期病例差异显著(P<0.05)。结论内膜异位症患者腹腔液中MCP-1、IGF-Ⅰ的变化在子宫内膜异位症发病机制中具有一定作用。Objeetive To investigate the role of monocyte chemotactic protein-1（MCP-1）and Insulin-like growth factors -Ⅰ （IGF-Ⅰ） in the endometriosis pathogenesis. Methods Peritoneal fluid and ectopic endometrial tissues of 30 patients with endometriosis （ 10 early stage and 20 severe stage） and 10 no-endometriosis were obtained .The ELISA was employed to measured MCP-1 and IGF-Ⅰ levels. Results The levels of MCP-land IGF-Ⅰ in the peritoneal fluid and ectopic endometrial tissues were significantly elevated in EM group as compared with those in the control group （ 10cases）（P 〈 0.01 ） ;the level of MCP-lof the peritoneal fluid and MCP-1 mass concentration of ectopic endometrial tissues were significantly higher in early stages than those in severe stages（P 〈 0.05）, but IGF- Ⅰ of the peritoneal fluid was significantly lower in early stages than that in severe stages （P 〈 0.05）. Conclusion The changes of MCP-1 and IGF- Ⅰ may play a role in the pathogenesis of endometriotic lesions.

关 键 词：子宫内膜异位症 胰岛素样生长因子Ⅰ 单核细胞趋化蛋白1 腹腔液 异位内膜组织 

分 类 号：R71[医药卫生—妇产科学]