超声波辐射下手性芳酰胺分子钳的合成及表征  

Synthesis and Characterization of Chiral Aromatic Amide Molecular Tweezer under Ultrasonic Radiation

作　　者：吕维忠[1] 刘波[1] 韦少慧[1] 

机构地区：[1]深圳大学化学与化工学院,广东深圳518060

出　　处：《精细化工》2008年第1期8-10,共3页Fine Chemicals

摘　　要：在超声波辐射下,以间苯二甲酸为隔离基,酰胺键桥联L-丙氨酸甲酯构成手臂,合成了手性芳酰胺分子钳。目标产物经IR、1HNMR、元素分析表征确认。结果表明:超声波辐射促进合成手性芳酰胺分子钳反应时间由传统合成法的1 440 min缩短为60 min,反应产率由59%提高到75%。合成的优化工艺参数为:n(间苯二甲酰氯)∶n(L-丙氨酸甲酯盐酸盐)=2∶7,反应时间60 min,超声波频率28 kHz,反应温度60℃。An aromatic amide molecular tweezer with chiral centers and cavities was synthesized under ultrasonic radiation using isophthalic acid as the spacer to bridge the L-alanine methyl ester. Its structure was characterized by ^1HNMR, IR spectra and elementary analysis. Compared with conventional method, the reaction time of sonochemical method was shortened from 1 440 min to 60 min and the yield increased from 59% to 75%. The optimum reaction conditions were： moles ratio of isophthalyl chloride to L-alanine methyl ester 2：7, reaction time 60 min,frequency of ultrasound 28 kHz and reaction temperature 60℃.

关 键 词：超声波辐射 芳酰胺 手性分子钳 合成 功能材料 

分 类 号：O621.3[理学—有机化学]