互穿网络水凝胶角膜接触镜材料的合成及性能  

Synthesis and Characteristics of Interpenetrating Network Hydrogel for Contact Lens

作　　者：鲁红[1] 黎新明[1] 崔英德[1] 廖列文[1] 尹国强[1] 

机构地区：[1]仲恺农业技术学院化学与化工系,广东广州510225

出　　处：《精细化工》2008年第1期77-82,93,共7页Fine Chemicals

基　　金：广东省自然科学基金(5300978)~~

摘　　要：通过高聚物分子设计的方法,运用互穿网络（IPN）技术,以吸水倍率为1.7的甲基丙烯酸β-羟乙酯（HEMA）水凝胶为基体材料,以吸水倍率为7-8的交联N^-乙烯基吡咯烷酮（PVPP）颗粒为分散相,制备出了互穿程度不同的复合水凝胶角膜接触镜材料。利用SEM和TG分析仪对合成物的结构及热稳定性进行了表征。结果表明,m（PVPP颗粒）∶m（单体HEMA）=10∶90,以w（甘油或PEG400）=35%-45%作致孔剂,通过控制液体HEMA在PVPP颗粒中的渗透程度,可制得膨润率2%-5.3%、拉伸强度430-695 kPa、透光率〉92%、含水质量分数45%左右的中等含水量的复合水凝胶角膜接触镜材料。DTG分析发现,在20-40℃,复合水凝胶的脱水速率随着互穿网络程度的提高而降低。The composite hydrogel for contact lens with different interpenetrating characteristic was prepared by the method of high polymer molecule design with β-hydroxyethyl methacrylate （HEMA） hydrogel as material, of whieh the water absorbency rate is 1.7, and PVPP particles as dispersing phase, of which the water absorbency rate is 7 to 8. The structure and the heat stability of product were characterized by SEM and TG analysis. The composite hydrogel for contact lens with expansion about 2% to 5.3% ,the strength from 430 kPa to 695 kPa, high transparency over 92% and medium water content about 45% could be attained by controlling the penetrating degree of HEMA in PVPP with m （PVPP） ： m （ HEM A） = 10：90, and w （ glycerin or PEG400 ） = 35 % - 45 % as the porogen. The DTG analysis results show that at 20℃ to 40℃ the dehydration velocity increases with the decrease of degree of interpenetrating.

关 键 词：角膜接触镜 IPN 复合水凝胶 高分子设计 甲基丙烯酸β-羟乙酯(HEMA) N-乙烯基吡咯烷酮(NVP) 医药与日化原料 

分 类 号：TQ050.425[化学工程]