有机催化不对称Mannich反应  

Organocatalytic Asymmetric Mannich Reaction

作　　者：马晶军[1] 李宁[1] 吴秋华[1] 周欣[1] 臧晓欢[1] 王春[1] 

机构地区：[1]河北农业大学理学院河北省生物无机化学重点实验室,保定071001

出　　处：《化学进展》2008年第1期76-86,共11页Progress in Chemistry

基　　金：河北省自然科学基金项目(No.299158);河北农业大学非生命学科科研发展基金项目(No.2005018)资助

摘　　要：有机催化的不对称合成反应是目前研究最为活跃的领域之一。不对称Mannich反应是合成光学活性β-氨基羰基化合物的有效手段。目前报道的催化不对称Mannich反应的有机催化剂主要有脯氨酸及其衍生物、手性磷酸、手性(硫)脲和金鸡纳碱衍生物等,取得了良好的催化活性和对映选择性。本文评述了各类有机催化剂在有机催化不对称Mannich反应中的应用研究进展,以及不对称诱导反应的机理、催化剂分子结构及反应条件对其催化活性和不对称诱导作用的影响。Organocatalytic asymmetric reaction is an increasingly active area in organic synthesis. Asymmetric Mannich reaction is a powerful tool for the synthesis of β-amino-carbonyl compounds. The reported organocatalyst for asymmetric Mannich reaction includes proline derivatives, chiral phosphoric acids, chiral （thio）urea derivatives, cinchona alkaloids etc. which can catalyze the asymmetric Mannich reaction with high catalytic activity and excellent enantioselectivity. The applications of various organocatalysts in asymmetric Mannich reaction are reviewed in this paper. The reaction mechanism, catalytic activity and the asymmetric induction influenced by the structure of organocatalysts and the reaction condition are also discussed.

关 键 词：有机催化 对映选择性 不对称Mannich反应 

分 类 号：O621.3[理学—有机化学] O623.1[理学—化学]